ENSMUSG00000044393


Mus musculus

Features
Gene ID: ENSMUSG00000044393
  
Biological name :Dsg2
  
Synonyms : Desmoglein-2 / Dsg2 / O55111
  
Possible biological names infered from orthology : Q14126
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A2
Gene start: 20558074
Gene end: 20604521
  
Corresponding Affymetrix probe sets: 10454172 (MoGene1.0st)   1425619_s_at (Mouse Genome 430 2.0 Array)   1426153_a_at (Mouse Genome 430 2.0 Array)   1439476_at (Mouse Genome 430 2.0 Array)   1449740_s_at (Mouse Genome 430 2.0 Array)   1449741_at (Mouse Genome 430 2.0 Array)   1460380_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057096
Ensembl peptide - ENSMUSP00000113029
Ensembl peptide - ENSMUSP00000113153
NCBI entrez gene - 13511     See in Manteia.
MGI - MGI:1196466
RefSeq - NM_007883
RefSeq Peptide - NP_031909
swissprot - O55111
swissprot - Q811I1
swissprot - Q8VCE3
Ensembl - ENSMUSG00000044393
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-74h11.1ENSDARG00000062750Danio rerio
 DSG2ENSGALG00000015142Gallus gallus
 DSG2ENSG00000046604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dsg3 / desmoglein 3 / P32926*ENSMUSG0000005663233
Dsg4 / Q7TMD7 / Desmoglein-4 / Q86SJ6*ENSMUSG0000000180433
Dsg1b / Q7TSF1 / Desmoglein-1-beta / DSG1* / Q02413* / desmoglein 1*ENSMUSG0000006192833
Dsg1a / Q61495 / Desmoglein-1-alpha / DSG1* / Q02413* / desmoglein 1*ENSMUSG0000006944133
Dsg1c / Q7TSF0 / Desmoglein-1-gamma / DSG1* / Q02413* / desmoglein 1*ENSMUSG0000003477430


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR009122  Desmosomal cadherin
 IPR009123  Desmoglein
 IPR013783  Immunoglobulin-like fold
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002934 desmosome organization IEA
 biological_processGO:0003165 Purkinje myocyte development IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0098911 regulation of ventricular cardiac muscle cell action potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030057 desmosome ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cell adhesion proteins
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Relnrl-6J/Relnrl-6J
Genetic Background: C57BL/6J-Relnrl-6J/J

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: Relnrl-6J/Relnrl-6J
Genetic Background: C57BL/6J-Relnrl-6J/J

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Relnrl-6J/Relnrl-6J
Genetic Background: C57BL/6J-Relnrl-6J/J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Relnrl-6J/Relnrl-6J
Genetic Background: C57BL/6J-Relnrl-6J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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