ENSG00000138794


Homo sapiens

Features
Gene ID: ENSG00000138794
  
Biological name :CASP6
  
Synonyms : CASP6 / caspase 6 / P55212
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q25
Gene start: 109688622
Gene end: 109703583
  
Corresponding Affymetrix probe sets: 209790_s_at (Human Genome U133 Plus 2.0 Array)   211464_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000285333
Ensembl peptide - ENSP00000427669
Ensembl peptide - ENSP00000424080
Ensembl peptide - ENSP00000265164
NCBI entrez gene - 839     See in Manteia.
OMIM - 601532
RefSeq - NM_032992
RefSeq - NM_001226
RefSeq Peptide - NP_001217
RefSeq Peptide - NP_116787
swissprot - P55212
swissprot - D6RHU3
swissprot - D6RBM3
Ensembl - ENSG00000138794
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp6ENSDARG00000093405Danio rerio
 casp6l1ENSDARG00000025608Danio rerio
 casp6l2ENSDARG00000070368Danio rerio
 CASP6ENSGALG00000012186Gallus gallus
 Casp6ENSMUSG00000027997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP3 / P42574 / caspase 3ENSG0000016430537
CASP7 / P55210 / caspase 7ENSG0000016580634
CASP8 / Q14790 / caspase 8ENSG0000006401232
CASP10 / Q92851 / caspase 10ENSG0000000340030
CASP9 / P55211 / caspase 9ENSG0000013290629
CASP2 / P42575 / caspase 2ENSG0000010614427
CASP14 / P31944 / caspase 14ENSG0000010514123


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR037554  Caspase-6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0030855 epithelial cell differentiation IEP
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0072734 cellular response to staurosporine IMP
 biological_processGO:0097194 execution phase of apoptosis IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
Breakdown of the nuclear lamina
TP53 Regulates Transcription of Caspase Activators and Caspases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000026025 VIM / P08670 / vimentin  / reaction
 ENSG00000113368 LMNB1 / P20700 / lamin B1  / reaction
 ENSG00000138794 CASP6 / P55212 / caspase 6  / complex
 ENSG00000182568 SATB1 / Q01826 / SATB homeobox 1  / reaction
 ENSG00000160789 LMNA / P02545 / lamin A/C  / reaction






 

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