ENSG00000106144


Homo sapiens

Features
Gene ID: ENSG00000106144
  
Biological name :CASP2
  
Synonyms : CASP2 / caspase 2 / P42575
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q34
Gene start: 143288215
Gene end: 143307696
  
Corresponding Affymetrix probe sets: 208050_s_at (Human Genome U133 Plus 2.0 Array)   209811_at (Human Genome U133 Plus 2.0 Array)   209812_x_at (Human Genome U133 Plus 2.0 Array)   211140_s_at (Human Genome U133 Plus 2.0 Array)   226032_at (Human Genome U133 Plus 2.0 Array)   226036_x_at (Human Genome U133 Plus 2.0 Array)   34449_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312664
Ensembl peptide - ENSP00000481929
Ensembl peptide - ENSP00000376656
Ensembl peptide - ENSP00000340030
NCBI entrez gene - 835     See in Manteia.
OMIM - 600639
RefSeq - NM_001224
RefSeq - NM_032982
RefSeq - NM_032983
RefSeq Peptide - NP_001215
RefSeq Peptide - NP_116764
RefSeq Peptide - NP_116765
swissprot - P42575
swissprot - A0A0S2Z3H1
swissprot - A0A087WYM1
swissprot - C9JRR9
Ensembl - ENSG00000106144
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp2ENSDARG00000062052Danio rerio
 CASP2ENSGALG00000014698Gallus gallus
 Casp2ENSMUSG00000029863Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP9 / P55211 / caspase 9ENSG0000013290625
CASP10 / Q92851 / caspase 10ENSG0000000340024
CASP8 / Q14790 / caspase 8ENSG0000006401222
CASP7 / P55210 / caspase 7ENSG0000016580618
CASP6 / P55212 / caspase 6ENSG0000013879417
CASP3 / P42574 / caspase 3ENSG0000016430517
CASP14 / P31944 / caspase 14ENSG0000010514115


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR035702  Caspase-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001554 luteolysis IEA
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage TAS
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0035234 ectopic germ cell programmed cell death IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding ISS
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
NADE modulates death signalling
TP53 Regulates Transcription of Caspase Activators and Caspases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106144 CASP2 / P42575 / caspase 2  / complex
 ENSG00000169372 CRADD / P78560 / CASP2 and RIPK1 domain containing adaptor with death domain  / reaction / complex
 ENSG00000166681 BEX3 / Q00994 / brain expressed X-linked 3  / reaction
 ENSG00000177595 PIDD1 / Q9HB75 / p53-induced death domain protein 1  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr