ENSGALG00000014698


Gallus gallus

Features
Gene ID: ENSGALG00000014698
  
Biological name :CASP2
  
Synonyms : CASP2 / caspase-2
  
Possible biological names infered from orthology : Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P29594 / P42575
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 77671018
Gene end: 77697005
  
Corresponding Affymetrix probe sets: Gga.14486.1.S1_at (Chicken Array)   Gga.504.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049604
Ensembl peptide - ENSGALP00000029853
NCBI entrez gene - 395857     See in Manteia.
RefSeq - XM_015293223
RefSeq - NM_001167701
RefSeq - XM_015293213
RefSeq Peptide - NP_001161173
swissprot - F1NP15
swissprot - A0A1D5PA44
Ensembl - ENSGALG00000014698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp2ENSDARG00000062052Danio rerio
 CASP2ENSG00000106144Homo sapiens
 Casp2ENSMUSG00000029863Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSGALG0000000136625
CASP10 / caspase 10 / Q92851*ENSGALG0000004649424
CASP8 / caspase-8 / O89110* / Q14790* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSGALG0000000835521
CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSGALG0000001063819
CASP18ENSGALG0000000834619
CASP6 / caspase-6 / O08738* / P55212* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSGALG0000001218618
CASP7 / caspase 7 / P55210* / P97864* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSGALG0000000893318


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0035234 ectopic germ cell programmed cell death IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TP53 Regulates Transcription of Caspase Activators and Caspases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011297 CRADD / CASP2 and RIPK1 domain containing adaptor with death domain / O88843* / P78560* / Mus musculus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), transcript varian...  / complex / reaction
 ENSGALG00000014698 CASP2 / caspase-2 / P29594* / P42575* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*  / complex
 ENSGALG00000040729 PIDD1 / p53-induced death domain protein 1 / Q9ERV7* / Q9HB75* / p53-induced death domain-containing protein 1 *  / reaction / complex






 

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