ENSMUSG00000029863


Mus musculus

Features
Gene ID: ENSMUSG00000029863
  
Biological name :Casp2
  
Synonyms : Casp2 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P29594
  
Possible biological names infered from orthology : caspase 2 / P42575
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.1
Gene start: 42264985
Gene end: 42282508
  
Corresponding Affymetrix probe sets: 10537728 (MoGene1.0st)   1448165_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121184
Ensembl peptide - ENSMUSP00000031895
NCBI entrez gene - 12366     See in Manteia.
MGI - MGI:97295
RefSeq - NM_007610
RefSeq Peptide - NP_031636
swissprot - D6RFN6
swissprot - P29594
Ensembl - ENSMUSG00000029863
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp2ENSDARG00000062052Danio rerio
 CASP2ENSGALG00000014698Gallus gallus
 CASP2ENSG00000106144Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*ENSMUSG0000002891427
Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*ENSMUSG0000002602922
Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*ENSMUSG0000002507618
Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*ENSMUSG0000003162816
Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*ENSMUSG0000002799716
Casp14 / O89094 / Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form / P31...ENSMUSG0000000535515
Casp16-ps / caspase 16, apoptosis-related cysteine peptidase, pseudogeneENSMUSG000000678828


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR035702  Caspase-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001554 luteolysis IEA
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0035234 ectopic germ cell programmed cell death IGI
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:0097194 execution phase of apoptosis IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity RCA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IDA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
NADE modulates death signalling
TP53 Regulates Transcription of Caspase Activators and Caspases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000909 abnormal facial motor nucleus morphology "malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Casp2tm1Vaux/Casp2tm1Vaux,Casp9tm1Flv/Casp9tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001025 abnormal sympathetic neuron morphology "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8tm1.1Jdes,Hoxd8tm1Jdes/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp2tm1Vaux/Casp2tm1Vaux,Casp9tm1Flv/Casp9tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0006361 abnormal female germ cell morphology "any structural anomaly female germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0008781 abnormal B cell apoptosis "change in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045867 Cradd / O88843 / Mus musculus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), transcript variant 3, mRNA. / P78560* / CASP2 and RIPK1 domain containing adaptor with death domain*  / reaction / complex
 ENSMUSG00000025507 Pidd1 / Q9ERV7 / p53-induced death domain-containing protein 1 / Q9HB75* / p53-induced death domain protein 1*  / reaction / complex
 ENSMUSG00000029863 Casp2 / P29594 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P42575* / caspase 2*  / complex
 ENSMUSG00000046432 Bex3 / Q9WTZ9 / Protein BEX3 / Q00994* / brain expressed X-linked 3*  / reaction






 

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