ENSMUSG00000045867


Mus musculus

Features
Gene ID: ENSMUSG00000045867
  
Biological name :Cradd
  
Synonyms : Cradd / Mus musculus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), transcript variant 3, mRNA. / O88843
  
Possible biological names infered from orthology : CASP2 and RIPK1 domain containing adaptor with death domain / P78560
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 95174746
Gene end: 95324133
  
Corresponding Affymetrix probe sets: 10372060 (MoGene1.0st)   1427505_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050295
Ensembl peptide - ENSMUSP00000151735
Ensembl peptide - ENSMUSP00000152022
NCBI entrez gene - 12905     See in Manteia.
MGI - MGI:1336168
RefSeq - XM_006513182
RefSeq - NM_001330141
RefSeq - NM_001330175
RefSeq - NM_009950
RefSeq - XM_006513178
RefSeq - XM_006513179
RefSeq - XM_006513180
RefSeq - XM_006513181
RefSeq Peptide - NP_001317067
RefSeq Peptide - NP_001317070
RefSeq Peptide - NP_001317104
RefSeq Peptide - NP_034080
swissprot - Q549T4
swissprot - O88843
Ensembl - ENSMUSG00000045867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 craddENSDARG00000028192Danio rerio
 CRADDENSGALG00000011297Gallus gallus
 CRADDENSG00000169372Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001315  CARD domain
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030674 protein binding, bridging ISO
 molecular_functionGO:0070513 death domain binding ISO


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Caspase Activators and Caspases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Sostdc1tm1Nit/Sostdc1tm1Nit
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sostdc1tm1Nit/Sostdc1tm1Nit
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Phb2tm1Katz/Phb2+
Genetic Background: 129S6/SvEvTac-Bcap37tm1Katz

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025507 Pidd1 / Q9ERV7 / p53-induced death domain-containing protein 1 / Q9HB75* / p53-induced death domain protein 1*  / complex / reaction
 ENSMUSG00000029863 Casp2 / P29594 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P42575* / caspase 2*  / reaction / complex
 ENSMUSG00000045867 Cradd / O88843 / Mus musculus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), transcript variant 3, mRNA. / P78560* / CASP2 and RIPK1 domain containing adaptor with death domain*  / complex / reaction






 

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