ENSMUSG00000025507


Mus musculus

Features
Gene ID: ENSMUSG00000025507
  
Biological name :Pidd1
  
Synonyms : p53-induced death domain-containing protein 1 / Pidd1 / Q9ERV7
  
Possible biological names infered from orthology : p53-induced death domain protein 1 / Q9HB75
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 141438113
Gene end: 141444025
  
Corresponding Affymetrix probe sets: 10569181 (MoGene1.0st)   1421397_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101627
Ensembl peptide - ENSMUSP00000139957
Ensembl peptide - ENSMUSP00000139785
Ensembl peptide - ENSMUSP00000139487
Ensembl peptide - ENSMUSP00000026580
NCBI entrez gene - 57913     See in Manteia.
MGI - MGI:1889507
RefSeq - XM_006536218
RefSeq - XM_011249849
RefSeq - XM_006536221
RefSeq - NM_022654
RefSeq - XM_006536220
RefSeq Peptide - NP_073145
swissprot - Q9ERV7
swissprot - A0A087WPX5
swissprot - A0A087WNT6
swissprot - A0A087WPI0
Ensembl - ENSMUSG00000025507
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pidd1ENSDARG00000074626Danio rerio
 PIDD1ENSGALG00000040729Gallus gallus
 PIDD1ENSG00000177595Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrch4 / Q921G6 / Leucine-rich repeat and calponin homology domain-containing protein 4 / O75427* / leucine rich repeats and calponin homology domain containing 4*ENSMUSG0000009344516
Lrch2 / Q3UMG5 / Leucine-rich repeat and calponin homology domain-containing protein 2 / Q5VUJ6* / leucine rich repeats and calponin homology domain containing 2*ENSMUSG0000003129016
Lrch3 / Q8BVU0 / Leucine-rich repeat and calponin homology domain-containing protein 3 / Q96II8* / leucine rich repeats and calponin homology domain containing 3*ENSMUSG0000002280116
Q921G6 / Gm20605 / predicted gene 20605 / LRCH4* / O75427* / leucine rich repeats and calponin homology domain containing 4*ENSMUSG0000002972016
Lrch1 / P62046 / Leucine-rich repeat and calponin homology domain-containing protein 1 / Q9Y2L9* / leucine rich repeats and calponin homology domain containing 1*ENSMUSG0000006801514
Lrrc69 / Q9D9Q0 / Leucine-rich repeat-containing protein 69 / Q6ZNQ3* / leucine rich repeat containing 69*ENSMUSG000000231519
Lrrc28 / Q3TX51 / Leucine-rich repeat-containing protein 28 / Q86X40* / leucine rich repeat containing 28*ENSMUSG000000305569
Lrrc8a / Q80WG5 / Volume-regulated anion channel subunit LRRC8A / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*ENSMUSG000000074768
Lrrc57 / leucine-rich repeat-containing protein 57 isoform a / Q8N9N7* / leucine rich repeat containing 57*ENSMUSG000000272868
Lrrc39 / Q8BGI7 / Leucine-rich repeat-containing protein 39 / Q96DD0* / leucine rich repeat containing 39*ENSMUSG000000279618
Lrsam1 / Q80ZI6 / E3 ubiquitin-protein ligase LRSAM1 / Q6UWE0* / leucine rich repeat and sterile alpha motif containing 1*ENSMUSG000000267928
Lrrc8e / Q66JT1 / Volume-regulated anion channel subunit LRRC8E / Q6NSJ5* / leucine rich repeat containing 8 VRAC subunit E*ENSMUSG000000465898
Q80WG5 / Gm28035 / predicted gene, 28035 / LRRC8A* / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*ENSMUSG000000990418
Lrrc18 / Q9CQ07 / Leucine-rich repeat-containing protein 18 / Q8N456* / leucine rich repeat containing 18*ENSMUSG000000416738
Lrrc8d / Q8BGR2 / Volume-regulated anion channel subunit LRRC8D / Q7L1W4* / leucine rich repeat containing 8 VRAC subunit D*ENSMUSG000000460797
Lrrc8b / Q5DU41 / Volume-regulated anion channel subunit LRRC8B / Q6P9F7* / leucine rich repeat containing 8 VRAC subunit B*ENSMUSG000000706397
Lrrc8c / Q8R502 / Volume-regulated anion channel subunit LRRC8C / Q8TDW0* / leucine rich repeat containing 8 VRAC subunit C*ENSMUSG000000547207
Rsu1 / Ras suppressor protein 1 / Q15404*ENSMUSG000000267276
Lrrc2 / leucine rich repeat containing 2 / Q9BYS8*ENSMUSG000000324956


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000906  ZU5 domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR011029  Death-like domain superfamily
 IPR019502  Peptidase S68, pidd
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Caspase Activators and Caspases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp7tm1.2Dgra/Bmp7tm1.2Dgra
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cJ * C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025507 Pidd1 / Q9ERV7 / p53-induced death domain-containing protein 1 / Q9HB75* / p53-induced death domain protein 1*  / reaction / complex
 ENSMUSG00000045867 Cradd / O88843 / Mus musculus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), transcript variant 3, mRNA. / P78560* / CASP2 and RIPK1 domain containing adaptor with death domain*  / reaction / complex
 ENSMUSG00000029863 Casp2 / P29594 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P42575* / caspase 2*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction






 

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