ENSMUSG00000046589


Mus musculus

Features
Gene ID: ENSMUSG00000046589
  
Biological name :Lrrc8e
  
Synonyms : Lrrc8e / Q66JT1 / Volume-regulated anion channel subunit LRRC8E
  
Possible biological names infered from orthology : leucine rich repeat containing 8 VRAC subunit E / Q6NSJ5
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 4226827
Gene end: 4237470
  
Corresponding Affymetrix probe sets: 10569923 (MoGene1.0st)   1438445_at (Mouse Genome 430 2.0 Array)   1456008_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052055
Ensembl peptide - ENSMUSP00000146637
NCBI entrez gene - 72267     See in Manteia.
MGI - MGI:1919517
RefSeq - XM_011242086
RefSeq - NM_028175
RefSeq - XM_006508906
RefSeq - XM_006508907
RefSeq - XM_006508908
RefSeq Peptide - NP_082451
swissprot - Q66JT1
swissprot - A0A140LI19
Ensembl - ENSMUSG00000046589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LRRC8EENSDARG00000078283Danio rerio
 LRRC8EENSG00000171017Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc8c / Q8R502 / Volume-regulated anion channel subunit LRRC8C / Q8TDW0* / leucine rich repeat containing 8 VRAC subunit C*ENSMUSG0000005472062
Q80WG5 / Gm28035 / predicted gene, 28035 / LRRC8A* / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*ENSMUSG0000009904154
Lrrc8a / Q80WG5 / Volume-regulated anion channel subunit LRRC8A / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*ENSMUSG0000000747654
Lrrc8d / Q8BGR2 / Volume-regulated anion channel subunit LRRC8D / Q7L1W4* / leucine rich repeat containing 8 VRAC subunit D*ENSMUSG0000004607951
Lrrc8b / Q5DU41 / Volume-regulated anion channel subunit LRRC8B / Q6P9F7* / leucine rich repeat containing 8 VRAC subunit B*ENSMUSG0000007063946
Lrsam1 / Q80ZI6 / E3 ubiquitin-protein ligase LRSAM1 / Q6UWE0* / leucine rich repeat and sterile alpha motif containing 1*ENSMUSG0000002679213
Q921G6 / Gm20605 / predicted gene 20605 / LRCH4* / O75427* / leucine rich repeats and calponin homology domain containing 4*ENSMUSG0000002972010
Lrch4 / Q921G6 / Leucine-rich repeat and calponin homology domain-containing protein 4 / O75427* / leucine rich repeats and calponin homology domain containing 4*ENSMUSG0000009344510
Lrch1 / P62046 / Leucine-rich repeat and calponin homology domain-containing protein 1 / Q9Y2L9* / leucine rich repeats and calponin homology domain containing 1*ENSMUSG000000680159
Pidd1 / Q9ERV7 / p53-induced death domain-containing protein 1 / Q9HB75* / p53-induced death domain protein 1*ENSMUSG000000255079
Lrch3 / Q8BVU0 / Leucine-rich repeat and calponin homology domain-containing protein 3 / Q96II8* / leucine rich repeats and calponin homology domain containing 3*ENSMUSG000000228019
Lrch2 / Q3UMG5 / Leucine-rich repeat and calponin homology domain-containing protein 2 / Q5VUJ6* / leucine rich repeats and calponin homology domain containing 2*ENSMUSG000000312908
Lrrc39 / Q8BGI7 / Leucine-rich repeat-containing protein 39 / Q96DD0* / leucine rich repeat containing 39*ENSMUSG000000279618
Lrrc69 / Q9D9Q0 / Leucine-rich repeat-containing protein 69 / Q6ZNQ3* / leucine rich repeat containing 69*ENSMUSG000000231518
Rsu1 / Ras suppressor protein 1 / Q15404*ENSMUSG000000267278
Lrrc28 / Q3TX51 / Leucine-rich repeat-containing protein 28 / Q86X40* / leucine rich repeat containing 28*ENSMUSG000000305568
Lrrc2 / leucine rich repeat containing 2 / Q9BYS8*ENSMUSG000000324957
Lrrc57 / leucine-rich repeat-containing protein 57 isoform a / Q8N9N7* / leucine rich repeat containing 57*ENSMUSG000000272866
Lrrc18 / Q9CQ07 / Leucine-rich repeat-containing protein 18 / Q8N456* / leucine rich repeat containing 18*ENSMUSG000000416735


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021040  LRRC8, pannexin-like TM region
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034702 ion channel complex IBA
 molecular_functionGO:0005225 volume-sensitive anion channel activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007476 Lrrc8a / Q80WG5 / Volume-regulated anion channel subunit LRRC8A / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*  / complex






 

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