ENSMUSG00000054720


Mus musculus

Features
Gene ID: ENSMUSG00000054720
  
Biological name :Lrrc8c
  
Synonyms : Lrrc8c / Q8R502 / Volume-regulated anion channel subunit LRRC8C
  
Possible biological names infered from orthology : leucine rich repeat containing 8 VRAC subunit C / Q8TDW0
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E5
Gene start: 105519388
Gene end: 105613018
  
Corresponding Affymetrix probe sets: 10523766 (MoGene1.0st)   1423614_at (Mouse Genome 430 2.0 Array)   1455398_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114899
Ensembl peptide - ENSMUSP00000122573
Ensembl peptide - ENSMUSP00000066015
NCBI entrez gene - 100604     See in Manteia.
MGI - MGI:2140839
RefSeq - XM_006534685
RefSeq - XM_006534686
RefSeq - XM_017320573
RefSeq - NM_133897
RefSeq Peptide - NP_598658
swissprot - Q8R502
swissprot - D3YUV5
swissprot - D3Z557
Ensembl - ENSMUSG00000054720
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc8cENSDARG00000099911Danio rerio
 LRRC8CENSGALG00000006170Gallus gallus
 LRRC8CENSG00000171488Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc8e / Q66JT1 / Volume-regulated anion channel subunit LRRC8E / Q6NSJ5* / leucine rich repeat containing 8 VRAC subunit E*ENSMUSG0000004658961
Q80WG5 / Gm28035 / predicted gene, 28035 / LRRC8A* / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*ENSMUSG0000009904157
Lrrc8a / Q80WG5 / Volume-regulated anion channel subunit LRRC8A / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*ENSMUSG0000000747657
Lrrc8d / Q8BGR2 / Volume-regulated anion channel subunit LRRC8D / Q7L1W4* / leucine rich repeat containing 8 VRAC subunit D*ENSMUSG0000004607952
Lrrc8b / Q5DU41 / Volume-regulated anion channel subunit LRRC8B / Q6P9F7* / leucine rich repeat containing 8 VRAC subunit B*ENSMUSG0000007063950
Lrsam1 / Q80ZI6 / E3 ubiquitin-protein ligase LRSAM1 / Q6UWE0* / leucine rich repeat and sterile alpha motif containing 1*ENSMUSG0000002679213
Q921G6 / Gm20605 / predicted gene 20605 / LRCH4* / O75427* / leucine rich repeats and calponin homology domain containing 4*ENSMUSG000000297209
Lrch4 / Q921G6 / Leucine-rich repeat and calponin homology domain-containing protein 4 / O75427* / leucine rich repeats and calponin homology domain containing 4*ENSMUSG000000934459
Lrch1 / P62046 / Leucine-rich repeat and calponin homology domain-containing protein 1 / Q9Y2L9* / leucine rich repeats and calponin homology domain containing 1*ENSMUSG000000680159
Lrrc39 / Q8BGI7 / Leucine-rich repeat-containing protein 39 / Q96DD0* / leucine rich repeat containing 39*ENSMUSG000000279618
Lrch2 / Q3UMG5 / Leucine-rich repeat and calponin homology domain-containing protein 2 / Q5VUJ6* / leucine rich repeats and calponin homology domain containing 2*ENSMUSG000000312908
Lrch3 / Q8BVU0 / Leucine-rich repeat and calponin homology domain-containing protein 3 / Q96II8* / leucine rich repeats and calponin homology domain containing 3*ENSMUSG000000228018
Lrrc2 / leucine rich repeat containing 2 / Q9BYS8*ENSMUSG000000324958
Pidd1 / Q9ERV7 / p53-induced death domain-containing protein 1 / Q9HB75* / p53-induced death domain protein 1*ENSMUSG000000255078
Lrrc28 / Q3TX51 / Leucine-rich repeat-containing protein 28 / Q86X40* / leucine rich repeat containing 28*ENSMUSG000000305568
Rsu1 / Ras suppressor protein 1 / Q15404*ENSMUSG000000267277
Lrrc69 / Q9D9Q0 / Leucine-rich repeat-containing protein 69 / Q6ZNQ3* / leucine rich repeat containing 69*ENSMUSG000000231517
Lrrc57 / leucine-rich repeat-containing protein 57 isoform a / Q8N9N7* / leucine rich repeat containing 57*ENSMUSG000000272865
Lrrc18 / Q9CQ07 / Leucine-rich repeat-containing protein 18 / Q8N456* / leucine rich repeat containing 18*ENSMUSG000000416735


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021040  LRRC8, pannexin-like TM region
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034702 ion channel complex IBA
 molecular_functionGO:0005225 volume-sensitive anion channel activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007476 Lrrc8a / Q80WG5 / Volume-regulated anion channel subunit LRRC8A / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*  / complex






 

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