ENSG00000171488


Homo sapiens

Features
Gene ID: ENSG00000171488
  
Biological name :LRRC8C
  
Synonyms : leucine rich repeat containing 8 VRAC subunit C / LRRC8C / Q8TDW0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p22.2
Gene start: 89633072
Gene end: 89769903
  
Corresponding Affymetrix probe sets: 1558517_s_at (Human Genome U133 Plus 2.0 Array)   1562712_at (Human Genome U133 Plus 2.0 Array)   1570007_at (Human Genome U133 Plus 2.0 Array)   223533_at (Human Genome U133 Plus 2.0 Array)   228314_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436638
Ensembl peptide - ENSP00000359483
NCBI entrez gene - 84230     See in Manteia.
OMIM - 612889
RefSeq - XM_017002504
RefSeq - NM_032270
RefSeq - XM_011542282
RefSeq - XM_011542283
RefSeq - XM_017002503
RefSeq - XM_006710960
RefSeq Peptide - NP_115646
swissprot - Q8TDW0
swissprot - E9PHY6
Ensembl - ENSG00000171488
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc8cENSDARG00000099911Danio rerio
 LRRC8CENSGALG00000006170Gallus gallus
 Lrrc8cENSMUSG00000054720Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC8E / Q6NSJ5 / leucine rich repeat containing 8 VRAC subunit EENSG0000017101762
LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit AENSG0000013680257
LRRC8D / Q7L1W4 / leucine rich repeat containing 8 VRAC subunit DENSG0000017149252
LRRC8B / Q6P9F7 / leucine rich repeat containing 8 VRAC subunit BENSG0000019714750
LRSAM1 / Q6UWE0 / leucine rich repeat and sterile alpha motif containing 1ENSG0000014835613
LRCH4 / O75427 / leucine rich repeats and calponin homology domain containing 4ENSG000000774549
LRCH1 / Q9Y2L9 / leucine rich repeats and calponin homology domain containing 1ENSG000001361419
LRRC39 / Q96DD0 / leucine rich repeat containing 39ENSG000001224779
PIDD1 / Q9HB75 / p53-induced death domain protein 1ENSG000001775958
LRCH2 / Q5VUJ6 / leucine rich repeats and calponin homology domain containing 2ENSG000001302248
LRCH3 / Q96II8 / leucine rich repeats and calponin homology domain containing 3ENSG000001860018
LRRC2 / Q9BYS8 / leucine rich repeat containing 2ENSG000001638278
LRRC69 / Q6ZNQ3 / leucine rich repeat containing 69ENSG000002149547
LRRC28 / Q86X40 / leucine rich repeat containing 28ENSG000001689047
RSU1 / Q15404 / Ras suppressor protein 1ENSG000001484847
LRRC57 / Q8N9N7 / leucine rich repeat containing 57ENSG000001809796
AC093423.3ENSG000002719496
LRRC18 / Q8N456 / leucine rich repeat containing 18ENSG000001653835


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021040  LRRC8, pannexin-like TM region
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0098656 anion transmembrane transport IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034702 ion channel complex IBA
 molecular_functionGO:0005225 volume-sensitive anion channel activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136802 LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit A  / complex






 

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