ENSG00000171492


Homo sapiens

Features
Gene ID: ENSG00000171492
  
Biological name :LRRC8D
  
Synonyms : leucine rich repeat containing 8 VRAC subunit D / LRRC8D / Q7L1W4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p22.2
Gene start: 89821014
Gene end: 89936611
  
Corresponding Affymetrix probe sets: 218684_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378093
Ensembl peptide - ENSP00000435609
Ensembl peptide - ENSP00000435504
Ensembl peptide - ENSP00000433422
Ensembl peptide - ENSP00000415117
Ensembl peptide - ENSP00000405784
Ensembl peptide - ENSP00000338887
NCBI entrez gene - 55144     See in Manteia.
OMIM - 612890
RefSeq - XM_011541689
RefSeq - XM_017001601
RefSeq - XM_017001600
RefSeq - NM_001134479
RefSeq - NM_018103
RefSeq - XM_017001599
RefSeq - XM_017001602
RefSeq Peptide - NP_060573
RefSeq Peptide - NP_001127951
swissprot - Q7L1W4
swissprot - Q5VWA0
swissprot - E9PMF9
swissprot - E9PJ89
swissprot - E9PJS7
swissprot - E9PL08
Ensembl - ENSG00000171492
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc8daENSDARG00000103370Danio rerio
 lrrc8dbENSDARG00000103840Danio rerio
 LRRC8DENSGALG00000020805Gallus gallus
 Lrrc8dENSMUSG00000046079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit AENSG0000013680253
LRRC8C / Q8TDW0 / leucine rich repeat containing 8 VRAC subunit CENSG0000017148849
LRRC8E / Q6NSJ5 / leucine rich repeat containing 8 VRAC subunit EENSG0000017101747
LRRC8B / Q6P9F7 / leucine rich repeat containing 8 VRAC subunit BENSG0000019714745
LRSAM1 / Q6UWE0 / leucine rich repeat and sterile alpha motif containing 1ENSG0000014835611
LRCH3 / Q96II8 / leucine rich repeats and calponin homology domain containing 3ENSG000001860019
LRCH4 / O75427 / leucine rich repeats and calponin homology domain containing 4ENSG000000774548
LRRC2 / Q9BYS8 / leucine rich repeat containing 2ENSG000001638278
LRCH1 / Q9Y2L9 / leucine rich repeats and calponin homology domain containing 1ENSG000001361418
LRRC39 / Q96DD0 / leucine rich repeat containing 39ENSG000001224778
LRRC69 / Q6ZNQ3 / leucine rich repeat containing 69ENSG000002149547
LRRC28 / Q86X40 / leucine rich repeat containing 28ENSG000001689047
PIDD1 / Q9HB75 / p53-induced death domain protein 1ENSG000001775957
LRCH2 / Q5VUJ6 / leucine rich repeats and calponin homology domain containing 2ENSG000001302247
RSU1 / Q15404 / Ras suppressor protein 1ENSG000001484846
LRRC18 / Q8N456 / leucine rich repeat containing 18ENSG000001653835
LRRC57 / Q8N9N7 / leucine rich repeat containing 57ENSG000001809794
AC093423.3ENSG000002719493


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021040  LRRC8, pannexin-like TM region
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0098656 anion transmembrane transport IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034702 ion channel complex IBA
 molecular_functionGO:0005225 volume-sensitive anion channel activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136802 LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit A  / complex






 

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