ENSG00000171017


Homo sapiens

Features
Gene ID: ENSG00000171017
  
Biological name :LRRC8E
  
Synonyms : leucine rich repeat containing 8 VRAC subunit E / LRRC8E / Q6NSJ5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.2
Gene start: 7888505
Gene end: 7902021
  
Corresponding Affymetrix probe sets: 220174_at (Human Genome U133 Plus 2.0 Array)   239433_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479953
Ensembl peptide - ENSP00000472642
Ensembl peptide - ENSP00000473127
Ensembl peptide - ENSP00000306524
Ensembl peptide - ENSP00000470302
Ensembl peptide - ENSP00000472491
NCBI entrez gene - 80131     See in Manteia.
OMIM - 612891
RefSeq - XM_011528319
RefSeq - NM_001268284
RefSeq - NM_001268285
RefSeq - NM_025061
RefSeq Peptide - NP_079337
RefSeq Peptide - NP_001255213
RefSeq Peptide - NP_001255214
swissprot - M0R2K8
swissprot - M0R3C1
swissprot - M0R2D8
swissprot - Q6NSJ5
swissprot - M0QZ48
Ensembl - ENSG00000171017
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LRRC8EENSDARG00000078283Danio rerio
 Lrrc8eENSMUSG00000046589Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC8C / Q8TDW0 / leucine rich repeat containing 8 VRAC subunit CENSG0000017148862
LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit AENSG0000013680254
LRRC8D / Q7L1W4 / leucine rich repeat containing 8 VRAC subunit DENSG0000017149251
LRRC8B / Q6P9F7 / leucine rich repeat containing 8 VRAC subunit BENSG0000019714746
LRSAM1 / Q6UWE0 / leucine rich repeat and sterile alpha motif containing 1ENSG0000014835612
LRCH3 / Q96II8 / leucine rich repeats and calponin homology domain containing 3ENSG0000018600110
LRCH4 / O75427 / leucine rich repeats and calponin homology domain containing 4ENSG0000007745410
PIDD1 / Q9HB75 / p53-induced death domain protein 1ENSG000001775959
LRCH1 / Q9Y2L9 / leucine rich repeats and calponin homology domain containing 1ENSG000001361419
LRCH2 / Q5VUJ6 / leucine rich repeats and calponin homology domain containing 2ENSG000001302249
LRRC28 / Q86X40 / leucine rich repeat containing 28ENSG000001689048
LRRC39 / Q96DD0 / leucine rich repeat containing 39ENSG000001224778
LRRC69 / Q6ZNQ3 / leucine rich repeat containing 69ENSG000002149548
LRRC2 / Q9BYS8 / leucine rich repeat containing 2ENSG000001638278
RSU1 / Q15404 / Ras suppressor protein 1ENSG000001484847
LRRC57 / Q8N9N7 / leucine rich repeat containing 57ENSG000001809796
AC093423.3ENSG000002719495
LRRC18 / Q8N456 / leucine rich repeat containing 18ENSG000001653835


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021040  LRRC8, pannexin-like TM region
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0098656 anion transmembrane transport IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034702 ion channel complex IBA
 molecular_functionGO:0005225 volume-sensitive anion channel activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136802 LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit A  / complex






 

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