ENSG00000197147


Homo sapiens

Features
Gene ID: ENSG00000197147
  
Biological name :LRRC8B
  
Synonyms : leucine rich repeat containing 8 VRAC subunit B / LRRC8B / Q6P9F7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p22.2
Gene start: 89524836
Gene end: 89597864
  
Corresponding Affymetrix probe sets: 212976_at (Human Genome U133 Plus 2.0 Array)   212978_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000491377
Ensembl peptide - ENSP00000400704
Ensembl peptide - ENSP00000492151
Ensembl peptide - ENSP00000332674
Ensembl peptide - ENSP00000350933
Ensembl peptide - ENSP00000395832
NCBI entrez gene - 23507     See in Manteia.
OMIM - 612888
RefSeq - XM_017000886
RefSeq - NM_001134476
RefSeq - NM_015350
RefSeq - XM_011541146
RefSeq - XM_011541148
RefSeq - XM_017000883
RefSeq - XM_017000884
RefSeq - XM_017000885
RefSeq - XM_005270701
RefSeq - XM_005270702
RefSeq - XM_005270703
RefSeq - XM_011541143
RefSeq - XM_011541144
RefSeq - XM_011541145
RefSeq Peptide - NP_001127948
RefSeq Peptide - NP_056165
swissprot - Q537H9
swissprot - Q6P9F7
swissprot - C9JGJ7
Ensembl - ENSG00000197147
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LRRC8BENSGALG00000006167Gallus gallus
 Lrrc8bENSMUSG00000070639Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit AENSG0000013680259
LRRC8C / Q8TDW0 / leucine rich repeat containing 8 VRAC subunit CENSG0000017148850
LRRC8D / Q7L1W4 / leucine rich repeat containing 8 VRAC subunit DENSG0000017149248
LRRC8E / Q6NSJ5 / leucine rich repeat containing 8 VRAC subunit EENSG0000017101746
LRSAM1 / Q6UWE0 / leucine rich repeat and sterile alpha motif containing 1ENSG0000014835613
LRCH4 / O75427 / leucine rich repeats and calponin homology domain containing 4ENSG0000007745410
LRRC2 / Q9BYS8 / leucine rich repeat containing 2ENSG000001638279
LRCH3 / Q96II8 / leucine rich repeats and calponin homology domain containing 3ENSG000001860019
PIDD1 / Q9HB75 / p53-induced death domain protein 1ENSG000001775958
LRRC39 / Q96DD0 / leucine rich repeat containing 39ENSG000001224778
LRCH1 / Q9Y2L9 / leucine rich repeats and calponin homology domain containing 1ENSG000001361418
LRCH2 / Q5VUJ6 / leucine rich repeats and calponin homology domain containing 2ENSG000001302248
RSU1 / Q15404 / Ras suppressor protein 1ENSG000001484847
LRRC28 / Q86X40 / leucine rich repeat containing 28ENSG000001689047
LRRC69 / Q6ZNQ3 / leucine rich repeat containing 69ENSG000002149547
LRRC57 / Q8N9N7 / leucine rich repeat containing 57ENSG000001809796
LRRC18 / Q8N456 / leucine rich repeat containing 18ENSG000001653835
AC093423.3ENSG000002719492


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021040  LRRC8, pannexin-like TM region
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0098656 anion transmembrane transport IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034702 ion channel complex IBA
 molecular_functionGO:0005225 volume-sensitive anion channel activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136802 LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit A  / complex






 

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