ENSG00000177595


Homo sapiens

Features
Gene ID: ENSG00000177595
  
Biological name :PIDD1
  
Synonyms : p53-induced death domain protein 1 / PIDD1 / Q9HB75
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 799179
Gene end: 809753
  
Corresponding Affymetrix probe sets: 219019_at (Human Genome U133 Plus 2.0 Array)   221640_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337797
Ensembl peptide - ENSP00000435008
Ensembl peptide - ENSP00000436146
Ensembl peptide - ENSP00000436342
Ensembl peptide - ENSP00000416801
NCBI entrez gene - 55367     See in Manteia.
OMIM - 605247
RefSeq - XM_017017993
RefSeq - XM_011520209
RefSeq - XM_011520210
RefSeq - XM_011520211
RefSeq - XM_011520212
RefSeq - XM_011520213
RefSeq - NM_145886
RefSeq - NM_145887
RefSeq - XM_005253005
RefSeq - XM_005253006
RefSeq - XM_005253007
RefSeq - XM_005253008
RefSeq Peptide - NP_665893
RefSeq Peptide - NP_665894
swissprot - H0YE55
swissprot - Q9HB75
swissprot - E9PPT6
Ensembl - ENSG00000177595
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pidd1ENSDARG00000074626Danio rerio
 PIDD1ENSGALG00000040729Gallus gallus
 Pidd1ENSMUSG00000025507Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRCH4 / O75427 / leucine rich repeats and calponin homology domain containing 4ENSG0000007745418
LRCH2 / Q5VUJ6 / leucine rich repeats and calponin homology domain containing 2ENSG0000013022415
LRCH3 / Q96II8 / leucine rich repeats and calponin homology domain containing 3ENSG0000018600115
LRCH1 / Q9Y2L9 / leucine rich repeats and calponin homology domain containing 1ENSG0000013614115
LRRC28 / Q86X40 / leucine rich repeat containing 28ENSG000001689049
LRSAM1 / Q6UWE0 / leucine rich repeat and sterile alpha motif containing 1ENSG000001483568
LRRC39 / Q96DD0 / leucine rich repeat containing 39ENSG000001224778
LRRC18 / Q8N456 / leucine rich repeat containing 18ENSG000001653838
LRRC57 / Q8N9N7 / leucine rich repeat containing 57ENSG000001809798
LRRC8E / Q6NSJ5 / leucine rich repeat containing 8 VRAC subunit EENSG000001710178
LRRC69 / Q6ZNQ3 / leucine rich repeat containing 69ENSG000002149548
LRRC8B / Q6P9F7 / leucine rich repeat containing 8 VRAC subunit BENSG000001971477
LRRC8C / Q8TDW0 / leucine rich repeat containing 8 VRAC subunit CENSG000001714887
LRRC2 / Q9BYS8 / leucine rich repeat containing 2ENSG000001638277
LRRC8A / Q8IWT6 / leucine rich repeat containing 8 VRAC subunit AENSG000001368027
LRRC8D / Q7L1W4 / leucine rich repeat containing 8 VRAC subunit DENSG000001714927
RSU1 / Q15404 / Ras suppressor protein 1ENSG000001484846
AC093423.3ENSG000002719490


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000906  ZU5 domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR011029  Death-like domain superfamily
 IPR019502  Peptidase S68, pidd
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005123 death receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Caspase Activators and Caspases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000106144 CASP2 / P42575 / caspase 2  / reaction / complex
 ENSG00000177595 PIDD1 / Q9HB75 / p53-induced death domain protein 1  / complex / reaction
 ENSG00000169372 CRADD / P78560 / CASP2 and RIPK1 domain containing adaptor with death domain  / reaction / complex






 

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