ENSMUSG00000026792


Mus musculus

Features
Gene ID: ENSMUSG00000026792
  
Biological name :Lrsam1
  
Synonyms : E3 ubiquitin-protein ligase LRSAM1 / Lrsam1 / Q80ZI6
  
Possible biological names infered from orthology : leucine rich repeat and sterile alpha motif containing 1 / Q6UWE0
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32925216
Gene end: 32961614
  
Corresponding Affymetrix probe sets: 10481734 (MoGene1.0st)   1429176_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108825
Ensembl peptide - ENSMUSP00000141713
Ensembl peptide - ENSMUSP00000141675
Ensembl peptide - ENSMUSP00000122877
Ensembl peptide - ENSMUSP00000122711
Ensembl peptide - ENSMUSP00000118604
Ensembl peptide - ENSMUSP00000117194
Ensembl peptide - ENSMUSP00000115830
Ensembl peptide - ENSMUSP00000028132
NCBI entrez gene - 227738     See in Manteia.
MGI - MGI:2684789
RefSeq - XM_006497972
RefSeq - XM_006497963
RefSeq - XM_006497964
RefSeq - XM_006497965
RefSeq - XM_006497966
RefSeq - XM_006497967
RefSeq - XM_006497968
RefSeq - XM_006497969
RefSeq - XM_006497970
RefSeq - XM_006497971
RefSeq - NM_199302
RefSeq - XM_006497962
RefSeq Peptide - NP_955006
swissprot - A2AHX3
swissprot - A2AHX2
swissprot - A0A0A6YWV2
swissprot - A0A0A6YWS5
swissprot - A2AHX5
swissprot - A2AHX6
swissprot - A2AHX4
swissprot - Q80ZI6
Ensembl - ENSMUSG00000026792
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrsam1ENSDARG00000060683Danio rerio
 LRSAM1ENSGALG00000008819Gallus gallus
 LRSAM1ENSG00000148356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc8a / Q80WG5 / Volume-regulated anion channel subunit LRRC8A / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*ENSMUSG0000000747615
Q80WG5 / Gm28035 / predicted gene, 28035 / LRRC8A* / Q8IWT6* / leucine rich repeat containing 8 VRAC subunit A*ENSMUSG0000009904115
Lrrc8b / Q5DU41 / Volume-regulated anion channel subunit LRRC8B / Q6P9F7* / leucine rich repeat containing 8 VRAC subunit B*ENSMUSG0000007063914
Lrrc8c / Q8R502 / Volume-regulated anion channel subunit LRRC8C / Q8TDW0* / leucine rich repeat containing 8 VRAC subunit C*ENSMUSG0000005472014
Lrrc8e / Q66JT1 / Volume-regulated anion channel subunit LRRC8E / Q6NSJ5* / leucine rich repeat containing 8 VRAC subunit E*ENSMUSG0000004658914
Lrrc8d / Q8BGR2 / Volume-regulated anion channel subunit LRRC8D / Q7L1W4* / leucine rich repeat containing 8 VRAC subunit D*ENSMUSG0000004607913
Lrch1 / P62046 / Leucine-rich repeat and calponin homology domain-containing protein 1 / Q9Y2L9* / leucine rich repeats and calponin homology domain containing 1*ENSMUSG0000006801511
Q921G6 / Gm20605 / predicted gene 20605 / LRCH4* / O75427* / leucine rich repeats and calponin homology domain containing 4*ENSMUSG0000002972011
Lrch4 / Q921G6 / Leucine-rich repeat and calponin homology domain-containing protein 4 / O75427* / leucine rich repeats and calponin homology domain containing 4*ENSMUSG0000009344511
Rsu1 / Ras suppressor protein 1 / Q15404*ENSMUSG0000002672710
Lrch3 / Q8BVU0 / Leucine-rich repeat and calponin homology domain-containing protein 3 / Q96II8* / leucine rich repeats and calponin homology domain containing 3*ENSMUSG0000002280110
Lrrc28 / Q3TX51 / Leucine-rich repeat-containing protein 28 / Q86X40* / leucine rich repeat containing 28*ENSMUSG000000305569
Pidd1 / Q9ERV7 / p53-induced death domain-containing protein 1 / Q9HB75* / p53-induced death domain protein 1*ENSMUSG000000255079
Lrch2 / Q3UMG5 / Leucine-rich repeat and calponin homology domain-containing protein 2 / Q5VUJ6* / leucine rich repeats and calponin homology domain containing 2*ENSMUSG000000312909
Lrrc69 / Q9D9Q0 / Leucine-rich repeat-containing protein 69 / Q6ZNQ3* / leucine rich repeat containing 69*ENSMUSG000000231518
Lrrc39 / Q8BGI7 / Leucine-rich repeat-containing protein 39 / Q96DD0* / leucine rich repeat containing 39*ENSMUSG000000279617
Lrrc18 / Q9CQ07 / Leucine-rich repeat-containing protein 18 / Q8N456* / leucine rich repeat containing 18*ENSMUSG000000416736
Lrrc2 / leucine rich repeat containing 2 / Q9BYS8*ENSMUSG000000324956
Lrrc57 / leucine-rich repeat-containing protein 57 isoform a / Q8N9N7* / leucine rich repeat containing 57*ENSMUSG000000272866


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001660  Sterile alpha motif domain
 IPR001841  Zinc finger, RING-type
 IPR003591  Leucine-rich repeat, typical subtype
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process ISS
 biological_processGO:0045806 negative regulation of endocytosis ISS
 biological_processGO:0046755 viral budding ISS
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:0070086 ubiquitin-dependent endocytosis ISO
 biological_processGO:1904417 positive regulation of xenophagy ISS
 biological_processGO:2000786 positive regulation of autophagosome assembly ISS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Mycntm1.1Mlit/Mycntm1.1Mlit,Tg(CAG-tTS)1Mlit/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Allelic Composition: Lrsam1Gt(RRK461)Byg/Lrsam1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd2tm1Sia/Pkd2tm1Sia
Genetic Background: Not Specified

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrsam1Gt(RRK461)Byg/Lrsam1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mycntm1.1Mlit/Mycntm1.1Mlit,Tg(CAG-tTS)1Mlit/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Allelic Composition: Lrsam1Gt(RRK461)Byg/Lrsam1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mycntm1.1Mlit/Mycntm1.1Mlit,Tg(CAG-tTS)1Mlit/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mycntm1.1Mlit/Mycntm1.1Mlit,Tg(CAG-tTS)1Mlit/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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