ENSDARG00000060683


Danio rerio

Features
Gene ID: ENSDARG00000060683
  
Biological name :lrsam1
  
Synonyms : leucine rich repeat and sterile alpha motif containing 1 / lrsam1
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase LRSAM1 / Q6UWE0 / Q80ZI6
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 32865364
Gene end: 32882162
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000080204
NCBI entrez gene - 562066     See in Manteia.
RefSeq - NM_001100004
RefSeq Peptide - NP_001093474
swissprot - A2CF42
ZFIN ID - ZDB-GENE-060526-97
Ensembl - ENSDARG00000060683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LRSAM1ENSGALG00000008819Gallus gallus
 LRSAM1ENSG00000148356Homo sapiens
 Lrsam1ENSMUSG00000026792Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lrrc8ab / leucine rich repeat containing 8 VRAC subunit Ab / Q8IWT6* / LRRC8A* / Q80WG5* / Gm28035* / predicted gene, 28035* / Volume-regulated anion channel subunit LRRC8A * / leucine rich...ENSDARG0000005215513
lrrc8c / leucine rich repeat containing 8 VRAC subunit C / Q8R502* / Q8TDW0* / Volume-regulated anion channel subunit LRRC8C *ENSDARG0000009991113
lrrc8aa / leucine rich repeat containing 8 VRAC subunit Aa / Q8IWT6* / LRRC8A* / Q80WG5* / Gm28035* / predicted gene, 28035* / Volume-regulated anion channel subunit LRRC8A * / leucine rich...ENSDARG0000003218813
si:ch211-106h11.1ENSDARG0000001772012
lrrc8da / leucine rich repeat containing 8 VRAC subunit Da / LRRC8D* / Q7L1W4* / Q8BGR2* / Volume-regulated anion channel subunit LRRC8D * / leucine rich repeat containing 8 VRAC subunit D*ENSDARG0000010337011
lrrc8db / leucine rich repeat containing 8 VRAC subunit Db / LRRC8D* / Q7L1W4* / Q8BGR2* / Volume-regulated anion channel subunit LRRC8D * / leucine rich repeat containing 8 VRAC subunit D*ENSDARG0000010384011
LRRC8E / si:zfos-323e3.4 / Q6NSJ5* / Q66JT1* / AC093423.3* / Volume-regulated anion channel subunit LRRC8E * / leucine rich repeat containing 8 VRAC subunit E*ENSDARG0000007828311
rsu1 / Ras suppressor protein 1 / Q15404*ENSDARG0000010288510
lrch4 / leucine-rich repeats and calponin homology (CH) domain containing 4 / Q921G6* / O75427* / Gm20605* / predicted gene 20605* / leucine rich repeats and calponin homology domain contai...ENSDARG000000682589
lrch1 / leucine-rich repeats and calponin homology (CH) domain containing 1 / P62046* / Q9Y2L9* / leucine rich repeats and calponin homology domain containing 1* / Leucine-rich repeat and c...ENSDARG000000787789
pidd1 / p53-induced death domain protein 1 / Q9ERV7* / Q9HB75* / p53-induced death domain-containing protein 1 *ENSDARG000000746268
lrch2 / leucine-rich repeats and calponin homology (CH) domain containing 2 / Q3UMG5* / Q5VUJ6* / leucine rich repeats and calponin homology domain containing 2* / Leucine-rich repeat and c...ENSDARG000000755808
lrrc28 / leucine rich repeat containing 28 / Q86X40*ENSDARG000000574778
lrch3 / leucine-rich repeats and calponin homology (CH) domain containing 3 / Q8BVU0* / Q96II8* / leucine rich repeats and calponin homology domain containing 3* / Leucine-rich repeat and c...ENSDARG000001006797
LRRC69 / si:ch73-302o18.2 / Q6ZNQ3* / Q9D9Q0* / leucine rich repeat containing 69* / Leucine-rich repeat-containing protein 69 *ENSDARG000000883167
si:dkey-1h4.4ENSDARG000001055486
lrrc57 / Q6DHL5 / leucine rich repeat containing 57 / Q8N9N7* / leucine-rich repeat-containing protein 57 isoform a *ENSDARG000000439386
F1R6I3 / lrrc39 / leucine rich repeat containing 39 / Q96DD0* / Q8BGI7* / Leucine-rich repeat-containing protein 39 *ENSDARG000000714656
lrrc18a / leucine rich repeat containing 18a / Q9CQ07* / LRRC18* / Q8N456* / leucine rich repeat containing 18* / Leucine-rich repeat-containing protein 18 *ENSDARG000000787906
lrrc18b / leucine rich repeat containing 18b / Q9CQ07* / LRRC18* / Q8N456* / leucine rich repeat containing 18* / Leucine-rich repeat-containing protein 18 *ENSDARG000000762366


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001660  Sterile alpha motif domain
 IPR001841  Zinc finger, RING-type
 IPR003591  Leucine-rich repeat, typical subtype
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0070086 ubiquitin-dependent endocytosis IBA
 biological_processGO:1904417 positive regulation of xenophagy IBA
 biological_processGO:2000786 positive regulation of autophagosome assembly IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000155 somite somite disorganized , abnormal
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 ZFA:0001094 whole organism whole organism decreased pigmentation , abnormal
whole organism anatomical axis decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
ventral wall of dorsal aorta decreased amount , abnormal
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 ZFA:0009052 motor neuron motor neuron disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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