ENSDARG00000052155


Danio rerio

Features
Gene ID: ENSDARG00000052155
  
Biological name :lrrc8ab
  
Synonyms : leucine rich repeat containing 8 VRAC subunit Ab / lrrc8ab
  
Possible biological names infered from orthology : Gm28035 / leucine rich repeat containing 8 VRAC subunit A / LRRC8A / predicted gene, 28035 / Q80WG5 / Q8IWT6 / Volume-regulated anion channel subunit LRRC8A
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 64840656
Gene end: 64850497
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000068442
Ensembl peptide - ENSDARP00000113341
NCBI entrez gene - 557928     See in Manteia.
swissprot - A2BF98
ZFIN ID - ZDB-GENE-060531-43
Ensembl - ENSDARG00000052155
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LRRC8AENSGALG00000004573Gallus gallus
 LRRC8AENSG00000136802Homo sapiens
 Lrrc8aENSMUSG00000007476Mus musculus
 Q80WG5ENSMUSG00000099041Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lrrc8aa / leucine rich repeat containing 8 VRAC subunit Aa / Q8IWT6* / LRRC8A* / Q80WG5* / Gm28035* / predicted gene, 28035* / Volume-regulated anion channel subunit LRRC8A * / leucine rich...ENSDARG0000003218889
lrrc8c / leucine rich repeat containing 8 VRAC subunit C / Q8R502* / Q8TDW0* / Volume-regulated anion channel subunit LRRC8C *ENSDARG0000009991158
lrrc8db / leucine rich repeat containing 8 VRAC subunit Db / LRRC8D* / Q7L1W4* / Q8BGR2* / Volume-regulated anion channel subunit LRRC8D * / leucine rich repeat containing 8 VRAC subunit D*ENSDARG0000010384057
lrrc8da / leucine rich repeat containing 8 VRAC subunit Da / LRRC8D* / Q7L1W4* / Q8BGR2* / Volume-regulated anion channel subunit LRRC8D * / leucine rich repeat containing 8 VRAC subunit D*ENSDARG0000010337054
LRRC8E / si:zfos-323e3.4 / Q6NSJ5* / Q66JT1* / AC093423.3* / Volume-regulated anion channel subunit LRRC8E * / leucine rich repeat containing 8 VRAC subunit E*ENSDARG0000007828350
si:ch211-106h11.1ENSDARG0000001772041
lrsam1 / leucine rich repeat and sterile alpha motif containing 1 / Q6UWE0* / Q80ZI6* / E3 ubiquitin-protein ligase LRSAM1 *ENSDARG0000006068312
F1R6I3 / lrrc39 / leucine rich repeat containing 39 / Q96DD0* / Q8BGI7* / Leucine-rich repeat-containing protein 39 *ENSDARG000000714659
lrch1 / leucine-rich repeats and calponin homology (CH) domain containing 1 / P62046* / Q9Y2L9* / leucine rich repeats and calponin homology domain containing 1* / Leucine-rich repeat and c...ENSDARG000000787789
lrch4 / leucine-rich repeats and calponin homology (CH) domain containing 4 / Q921G6* / O75427* / Gm20605* / predicted gene 20605* / leucine rich repeats and calponin homology domain contai...ENSDARG000000682589
rsu1 / Ras suppressor protein 1 / Q15404*ENSDARG000001028858
lrch2 / leucine-rich repeats and calponin homology (CH) domain containing 2 / Q3UMG5* / Q5VUJ6* / leucine rich repeats and calponin homology domain containing 2* / Leucine-rich repeat and c...ENSDARG000000755808
lrch3 / leucine-rich repeats and calponin homology (CH) domain containing 3 / Q8BVU0* / Q96II8* / leucine rich repeats and calponin homology domain containing 3* / Leucine-rich repeat and c...ENSDARG000001006797
lrrc28 / leucine rich repeat containing 28 / Q86X40*ENSDARG000000574777
LRRC69 / si:ch73-302o18.2 / Q6ZNQ3* / Q9D9Q0* / leucine rich repeat containing 69* / Leucine-rich repeat-containing protein 69 *ENSDARG000000883167
si:dkey-1h4.4ENSDARG000001055486
lrrc18b / leucine rich repeat containing 18b / Q9CQ07* / LRRC18* / Q8N456* / leucine rich repeat containing 18* / Leucine-rich repeat-containing protein 18 *ENSDARG000000762366
lrrc18a / leucine rich repeat containing 18a / Q9CQ07* / LRRC18* / Q8N456* / leucine rich repeat containing 18* / Leucine-rich repeat-containing protein 18 *ENSDARG000000787906
pidd1 / p53-induced death domain protein 1 / Q9ERV7* / Q9HB75* / p53-induced death domain-containing protein 1 *ENSDARG000000746266
lrrc57 / Q6DHL5 / leucine rich repeat containing 57 / Q8N9N7* / leucine-rich repeat-containing protein 57 isoform a *ENSDARG000000439385


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021040  LRRC8, pannexin-like TM region
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0098656 anion transmembrane transport IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034702 ion channel complex IBA
 molecular_functionGO:0005225 volume-sensitive anion channel activity IBA


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000078283 LRRC8E / si:zfos-323e3.4 / Q6NSJ5* / Q66JT1* / AC093423.3* / Volume-regulated anion channel subunit LRRC8E * / leucine rich repeat containing 8 VRAC subunit E*  / complex
 ENSDARG00000103840 lrrc8db / leucine rich repeat containing 8 VRAC subunit Db / LRRC8D* / Q7L1W4* / Q8BGR2* / Volume-regulated anion channel subunit LRRC8D * / leucine rich repeat containing 8 VRAC subunit D*  / complex
 ENSDARG00000103370 lrrc8da / leucine rich repeat containing 8 VRAC subunit Da / LRRC8D* / Q7L1W4* / Q8BGR2* / Volume-regulated anion channel subunit LRRC8D * / leucine rich repeat containing 8 VRAC subunit D*  / complex
 ENSDARG00000099911 lrrc8c / leucine rich repeat containing 8 VRAC subunit C / Q8R502* / Q8TDW0* / Volume-regulated anion channel subunit LRRC8C *  / complex






 

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