ENSGALG00000004573


Gallus gallus

Features
Gene ID: ENSGALG00000004573
  
Biological name :LRRC8A
  
Synonyms : leucine rich repeat containing 8 VRAC subunit A / LRRC8A
  
Possible biological names infered from orthology : Gm28035 / predicted gene, 28035 / Q80WG5 / Q8IWT6 / Volume-regulated anion channel subunit LRRC8A
  
Species: Gallus gallus
  
Chr. number: 17
Strand: 1
Band:
Gene start: 5843159
Gene end: 5848437
  
Corresponding Affymetrix probe sets: Gga.10852.1.S1_s_at (Chicken Array)   Gga.19636.1.S1_s_at (Chicken Array)   GgaAffx.26247.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007267
Ensembl peptide - ENSGALP00000044227
NCBI entrez gene - 417201     See in Manteia.
RefSeq - XM_015279570
RefSeq - XM_015279568
RefSeq - XM_015279569
RefSeq - XM_003642283
RefSeq - XM_015279567
swissprot - E1BQK4
swissprot - A0A1D5NV54
Ensembl - ENSGALG00000004573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc8aaENSDARG00000032188Danio rerio
 lrrc8abENSDARG00000052155Danio rerio
 LRRC8AENSG00000136802Homo sapiens
 Lrrc8aENSMUSG00000007476Mus musculus
 Q80WG5ENSMUSG00000099041Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC8C / leucine rich repeat containing 8 VRAC subunit C / Q8R502* / Q8TDW0* / Volume-regulated anion channel subunit LRRC8C *ENSGALG0000000617058
LRRC8B / leucine rich repeat containing 8 VRAC subunit B / Q5DU41* / Q6P9F7* / Volume-regulated anion channel subunit LRRC8B *ENSGALG0000000616757
LRRC8D / leucine rich repeat containing 8 VRAC subunit D / Q7L1W4* / Q8BGR2* / Volume-regulated anion channel subunit LRRC8D *ENSGALG0000002080555
LRSAM1 / leucine rich repeat and sterile alpha motif containing 1 / Q6UWE0* / Q80ZI6* / E3 ubiquitin-protein ligase LRSAM1 *ENSGALG0000000881912
LRCH1 / leucine rich repeats and calponin homology domain containing 1 / P62046* / Q9Y2L9* / Leucine-rich repeat and calponin homology domain-containing protein 1 *ENSGALG0000001699010
LRRC39 / leucine rich repeat containing 39 / Q8BGI7* / Q96DD0* / Leucine-rich repeat-containing protein 39 *ENSGALG000000052849
LRRC28 / leucine rich repeat containing 28 / Q3TX51* / Q86X40* / Leucine-rich repeat-containing protein 28 *ENSGALG000000070578
LRCH2 / leucine rich repeats and calponin homology domain containing 2 / Q3UMG5* / Q5VUJ6* / Leucine-rich repeat and calponin homology domain-containing protein 2 *ENSGALG000000058828
LRCH3 / leucine rich repeats and calponin homology domain containing 3 / Q8BVU0* / Q96II8* / Leucine-rich repeat and calponin homology domain-containing protein 3 *ENSGALG000000075958
PIDD1 / p53-induced death domain protein 1 / Q9ERV7* / Q9HB75* / p53-induced death domain-containing protein 1 *ENSGALG000000407298
LRRC2 / leucine rich repeat containing 2 / Q9BYS8*ENSGALG000000136348
RSU1 / Ras suppressor protein 1 / Q15404*ENSGALG000000408917
LRRC18 / leucine rich repeat containing 18 / Q8N456* / Q9CQ07* / Leucine-rich repeat-containing protein 18 *ENSGALG000000061686
LRRC57 / leucine rich repeat containing 57 / Q8N9N7* / leucine-rich repeat-containing protein 57 isoform a *ENSGALG000000091125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021040  LRRC8, pannexin-like TM region
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0006884 cell volume homeostasis IEA
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0098656 anion transmembrane transport IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034702 ion channel complex IEA
 molecular_functionGO:0005225 volume-sensitive anion channel activity IEA
 molecular_functionGO:0005253 anion channel activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006170 LRRC8C / leucine rich repeat containing 8 VRAC subunit C / Q8R502* / Q8TDW0* / Volume-regulated anion channel subunit LRRC8C *  / complex
 ENSGALG00000020805 LRRC8D / leucine rich repeat containing 8 VRAC subunit D / Q7L1W4* / Q8BGR2* / Volume-regulated anion channel subunit LRRC8D *  / complex
 ENSGALG00000006167 LRRC8B / leucine rich repeat containing 8 VRAC subunit B / Q5DU41* / Q6P9F7* / Volume-regulated anion channel subunit LRRC8B *  / complex






 

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