ENSDARG00000062052


Danio rerio

Features
Gene ID: ENSDARG00000062052
  
Biological name :casp2
  
Synonyms : casp2 / caspase 2, apoptosis-related cysteine peptidase
  
Possible biological names infered from orthology : caspase 2 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P29594 / P42575
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 17548695
Gene end: 17578503
  
Corresponding Affymetrix probe sets: Dr.12787.2.A1_a_at (Zebrafish Array)   NM_001042695_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000108155
Ensembl peptide - ENSDARP00000148777
Ensembl peptide - ENSDARP00000115348
Ensembl peptide - ENSDARP00000083663
Ensembl peptide - ENSDARP00000105801
NCBI entrez gene - 373118     See in Manteia.
RefSeq - NM_001042695
RefSeq Peptide - NP_001036160
swissprot - A0A288CG41
swissprot - F1Q9Y1
swissprot - A6H8R3
swissprot - Q0PKX3
ZFIN ID - ZDB-GENE-030825-3
Ensembl - ENSDARG00000062052
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CASP2ENSGALG00000014698Gallus gallus
 CASP2ENSG00000106144Homo sapiens
 Casp2ENSMUSG00000029863Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
casp9 / caspase 9, apoptosis-related cysteine peptidase / P55211* / Q8C3Q9* / caspase 9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSDARG0000000432525
casp8 / caspase 8, apoptosis-related cysteine peptidase / Q14790* / O89110* / caspase 8* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSDARG0000005832524
si:dkey-103e21.5ENSDARG0000009192622
casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*ENSDARG0000007027220
casp6 / caspase 6, apoptosis-related cysteine peptidase / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000009340520
casp7 / caspase 7, apoptosis-related cysteine peptidase / P97864* / P55210* / caspase 7* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSDARG0000009183620
zgc:194469ENSDARG0000010436719
casp3b / caspase 3, apoptosis-related cysteine peptidase b / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000005504519
casp3a / caspase 3, apoptosis-related cysteine peptidase a / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000001790518
FO834888.1ENSDARG0000005555018
casp6l2 / caspase 6, apoptosis-related cysteine peptidase, like 2 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000007036817
casp6l1 / caspase 6, apoptosis-related cysteine peptidase, like 1 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000002560817
CU467905.1ENSDARG0000011257515
CR925773.1ENSDARG0000008626611


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IGI
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
 biological_processGO:0097194 execution phase of apoptosis IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TP53 Regulates Transcription of Caspase Activators and Caspases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028192 cradd / CASP2 and RIPK1 domain containing adaptor with death domain / O88843* / P78560* / Mus musculus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), transcript varian...  / reaction / complex
 ENSDARG00000062052 casp2 / caspase 2, apoptosis-related cysteine peptidase / P42575* / P29594* / caspase 2* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*  / complex
 ENSDARG00000074626 pidd1 / p53-induced death domain protein 1 / Q9ERV7* / Q9HB75* / p53-induced death domain-containing protein 1 *  / reaction / complex






 

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