ENSDARG00000058325


Danio rerio

Features
Gene ID: ENSDARG00000058325
  
Biological name :casp8
  
Synonyms : casp8 / caspase 8, apoptosis-related cysteine peptidase
  
Possible biological names infered from orthology : caspase 8 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / O89110 / Q14790
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 13045885
Gene end: 13058979
  
Corresponding Affymetrix probe sets: Dr.10334.1.S1_at (Zebrafish Array)   NM_131510_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000095527
Ensembl peptide - ENSDARP00000136351
NCBI entrez gene - 58022     See in Manteia.
RefSeq - XM_005165837
RefSeq - NM_131510
RefSeq Peptide - NP_571585
swissprot - F1QLH0
swissprot - A0A0R4IP27
ZFIN ID - ZDB-GENE-000713-1
Ensembl - ENSDARG00000058325
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CASP18ENSGALG00000008346Gallus gallus
 CASP8ENSGALG00000008355Gallus gallus
 CASP8ENSG00000064012Homo sapiens
 Casp8ENSMUSG00000026029Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*ENSDARG0000007027232
zgc:194469ENSDARG0000010436724
si:dkey-103e21.5ENSDARG0000009192624
casp7 / caspase 7, apoptosis-related cysteine peptidase / P97864* / P55210* / caspase 7* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSDARG0000009183621
casp2 / caspase 2, apoptosis-related cysteine peptidase / P42575* / P29594* / caspase 2* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSDARG0000006205220
casp9 / caspase 9, apoptosis-related cysteine peptidase / P55211* / Q8C3Q9* / caspase 9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSDARG0000000432520
casp6 / caspase 6, apoptosis-related cysteine peptidase / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000009340519
casp3a / caspase 3, apoptosis-related cysteine peptidase a / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000001790519
FO834888.1ENSDARG0000005555018
casp3b / caspase 3, apoptosis-related cysteine peptidase b / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000005504518
casp6l1 / caspase 6, apoptosis-related cysteine peptidase, like 1 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000002560817
casp6l2 / caspase 6, apoptosis-related cysteine peptidase, like 2 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000007036817
CU467905.1ENSDARG0000011257515
CR925773.1ENSDARG0000008626611


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IBA
 biological_processGO:0019051 induction by virus of host apoptotic process IMP
 biological_processGO:0030225 macrophage differentiation IBA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
 biological_processGO:0097194 execution phase of apoptosis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Dimerization of procaspase-8
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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