ENSDARG00000055045


Danio rerio

Features
Gene ID: ENSDARG00000055045
  
Biological name :casp3b
  
Synonyms : casp3b / caspase 3, apoptosis-related cysteine peptidase b
  
Possible biological names infered from orthology : CASP3 / caspase 3 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574 / P70677
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 4125363
Gene end: 4145594
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000071815
NCBI entrez gene - 566604     See in Manteia.
swissprot - F1Q7K7
ZFIN ID - ZDB-GENE-070607-1
Ensembl - ENSDARG00000055045
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CASP3ENSGALG00000010638Gallus gallus
 CASP3ENSG00000164305Homo sapiens
 Casp3ENSMUSG00000031628Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
casp3a / caspase 3, apoptosis-related cysteine peptidase a / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000001790558
casp7 / caspase 7, apoptosis-related cysteine peptidase / P97864* / P55210* / caspase 7* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSDARG0000009183652
FO834888.1ENSDARG0000005555036
casp6 / caspase 6, apoptosis-related cysteine peptidase / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000009340534
casp6l1 / caspase 6, apoptosis-related cysteine peptidase, like 1 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000002560833
casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*ENSDARG0000007027232
casp8 / caspase 8, apoptosis-related cysteine peptidase / Q14790* / O89110* / caspase 8* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSDARG0000005832531
casp6l2 / caspase 6, apoptosis-related cysteine peptidase, like 2 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000007036831
si:dkey-103e21.5ENSDARG0000009192630
zgc:194469ENSDARG0000010436730
casp9 / caspase 9, apoptosis-related cysteine peptidase / P55211* / Q8C3Q9* / caspase 9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSDARG0000000432529
casp2 / caspase 2, apoptosis-related cysteine peptidase / P42575* / P29594* / caspase 2* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSDARG0000006205226
CU467905.1ENSDARG0000011257526
CR925773.1ENSDARG0000008626621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030216 keratinocyte differentiation IBA
 biological_processGO:0030218 erythrocyte differentiation IBA
 biological_processGO:0097194 execution phase of apoptosis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Activation of caspases through apoptosome-mediated cleavage
Apoptotic cleavage of cellular proteins
Signaling by Hippo
Activation of DNA fragmentation factor
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
via Dependence Receptors in the absence of ligand
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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