ENSDARG00000070272


Danio rerio

Features
Gene ID: ENSDARG00000070272
  
Biological name :casp8l2
  
Synonyms : casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2
  
Possible biological names infered from orthology : CASP10 / caspase 10 / Q92851
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 1313418
Gene end: 1357809
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000149430
Ensembl peptide - ENSDARP00000156873
Ensembl peptide - ENSDARP00000024255
Ensembl peptide - ENSDARP00000076913
Ensembl peptide - ENSDARP00000115080
NCBI entrez gene - 557302     See in Manteia.
swissprot - E7EXV8
swissprot - F1Q7E9
swissprot - F1QRT9
ZFIN ID - ZDB-GENE-070608-2
Ensembl - ENSDARG00000070272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CASP10ENSGALG00000046494Gallus gallus
 CASP10ENSG00000003400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
casp8 / caspase 8, apoptosis-related cysteine peptidase / Q14790* / O89110* / caspase 8* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSDARG0000005832528
si:dkey-103e21.5ENSDARG0000009192622
zgc:194469ENSDARG0000010436721
casp9 / caspase 9, apoptosis-related cysteine peptidase / P55211* / Q8C3Q9* / caspase 9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSDARG0000000432518
casp7 / caspase 7, apoptosis-related cysteine peptidase / P97864* / P55210* / caspase 7* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSDARG0000009183618
casp3a / caspase 3, apoptosis-related cysteine peptidase a / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000001790517
casp6l2 / caspase 6, apoptosis-related cysteine peptidase, like 2 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000007036816
casp6 / caspase 6, apoptosis-related cysteine peptidase / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000009340516
casp3b / caspase 3, apoptosis-related cysteine peptidase b / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000005504516
casp6l1 / caspase 6, apoptosis-related cysteine peptidase, like 1 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000002560815
FO834888.1ENSDARG0000005555014
casp2 / caspase 2, apoptosis-related cysteine peptidase / P42575* / P29594* / caspase 2* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSDARG0000006205214
CU467905.1ENSDARG0000011257513
CR925773.1ENSDARG0000008626610


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
FasL/ CD95L signaling
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004392 hdr / hematopoietic death receptor / Q9QZM4* / Q9UBN6* / O00220* / O14763* / O14798* / TNFRSF10D* / TNFRSF10C* / TNFRSF10B* / TNFRSF10A* / TNF receptor superfamily member 10a* / TNF recepto...  / reaction / complex
 ENSDARG00000043586 fas / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction
 ENSDARG00000057241 tnfsf10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*  / reaction / complex
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / reaction / complex
 ENSDARG00000098913 faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*  / complex / reaction






 

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