ENSDARG00000004392


Danio rerio

Features
Gene ID: ENSDARG00000004392
  
Biological name :hdr
  
Synonyms : hdr / hematopoietic death receptor
  
Possible biological names infered from orthology : O00220 / O14763 / O14798 / Q9QZM4 / Q9UBN6 / TNF receptor superfamily member 10a / TNF receptor superfamily member 10b / TNF receptor superfamily member 10c / TNF receptor superfamily member 10d / TNFRSF10A / TNFRSF10B / TNFRSF10C / TNFRSF10D / Tumor necrosis factor receptor superfamily member 10B
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 27404946
Gene end: 27415081
  
Corresponding Affymetrix probe sets: DrAffx.1.39.S1_at (Zebrafish Array)   DrAffx.2.46.S1_at (Zebrafish Array)   NM_194391_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000012354
Ensembl peptide - ENSDARP00000105084
NCBI entrez gene - 373093     See in Manteia.
RefSeq - NM_194391
RefSeq Peptide - NP_919372
swissprot - F1QD95
swissprot - A3KPR7
ZFIN ID - ZDB-GENE-030826-5
Ensembl - ENSDARG00000004392
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDTNFR23ENSGALG00000006407Gallus gallus
 TNFRSF10BENSGALG00000000452Gallus gallus
 O00220ENSG00000104689Homo sapiens
 O14763ENSG00000120889Homo sapiens
 O14798ENSG00000173535Homo sapiens
 Q9UBN6ENSG00000173530Homo sapiens
 Q9QZM4ENSMUSG00000022074Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnfrsfa / tumor necrosis factor receptor superfamily, member a / O14798* / Q9QZM4* / Q9UBN6* / O14763* / O00220* / TNFRSF10C* / TNFRSF10D* / TNFRSF10A* / TNFRSF10B* / TNF receptor superfami...ENSDARG0000000445134


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR034024  Tumor necrosis factor receptor 10, N-terminal
 IPR034029  Tumour necrosis factor receptor 10A/B, death domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000070272 casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*  / complex / reaction
 ENSDARG00000055966 cflara / CASP8 and FADD-like apoptosis regulator a / CFLAR* / O35732* / O15519* / CASP8 and FADD like apoptosis regulator* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apop...  / reaction / complex
 ENSDARG00000004392 hdr / hematopoietic death receptor / Q9QZM4* / Q9UBN6* / O00220* / O14763* / O14798* / TNFRSF10D* / TNFRSF10C* / TNFRSF10B* / TNFRSF10A* / TNF receptor superfamily member 10a* / TNF recepto...  / reaction / complex
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSDARG00000057241 tnfsf10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*  / complex / reaction






 

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