ENSG00000173530


Homo sapiens

Features
Gene ID: ENSG00000173530
  
Biological name :TNFRSF10D
  
Synonyms : Q9UBN6 / TNF receptor superfamily member 10d / TNFRSF10D
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.3
Gene start: 23135588
Gene end: 23164030
  
Corresponding Affymetrix probe sets: 210654_at (Human Genome U133 Plus 2.0 Array)   227345_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000310263
NCBI entrez gene - 8793     See in Manteia.
OMIM - 603614
RefSeq - NM_003840
RefSeq Peptide - NP_003831
swissprot - Q9UBN6
Ensembl - ENSG00000173530
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdrENSDARG00000004392Danio rerio
 tnfrsfaENSDARG00000004451Danio rerio
 TNFRSF10BENSGALG00000000452Gallus gallus
 Q9QZM4ENSMUSG00000022074Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O14763 / TNFRSF10B / TNF receptor superfamily member 10bENSG0000012088952
O00220 / TNFRSF10A / TNF receptor superfamily member 10aENSG0000010468947
O14798 / TNFRSF10C / TNF receptor superfamily member 10cENSG0000017353535


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR020465  Tumour necrosis factor receptor 10
 IPR034024  Tumor necrosis factor receptor 10, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0045569 TRAIL binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
TP53 Regulates Transcription of Death Receptors and Ligands
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104689 O00220 / TNFRSF10A / TNF receptor superfamily member 10a  / complex / reaction
 ENSG00000120889 O14763 / TNFRSF10B / TNF receptor superfamily member 10b  / reaction / complex
 ENSG00000173530 Q9UBN6 / TNFRSF10D / TNF receptor superfamily member 10d  / reaction






 

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