ENSG00000104689


Homo sapiens

Features
Gene ID: ENSG00000104689
  
Biological name :TNFRSF10A
  
Synonyms : O00220 / TNF receptor superfamily member 10a / TNFRSF10A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.3
Gene start: 23190452
Gene end: 23225126
  
Corresponding Affymetrix probe sets: 1552648_a_at (Human Genome U133 Plus 2.0 Array)   231775_at (Human Genome U133 Plus 2.0 Array)   241371_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428884
Ensembl peptide - ENSP00000480778
Ensembl peptide - ENSP00000221132
NCBI entrez gene - 8797     See in Manteia.
OMIM - 603611
RefSeq - NM_003844
RefSeq Peptide - NP_003835
swissprot - E5RFH1
swissprot - F8U8C0
swissprot - O00220
Ensembl - ENSG00000104689
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdrENSDARG00000004392Danio rerio
 tnfrsfaENSDARG00000004451Danio rerio
 TNFRSF10BENSGALG00000000452Gallus gallus
 Q9QZM4ENSMUSG00000022074Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O14763 / TNFRSF10B / TNF receptor superfamily member 10bENSG0000012088949
Q9UBN6 / TNFRSF10D / TNF receptor superfamily member 10dENSG0000017353039
O14798 / TNFRSF10C / TNF receptor superfamily member 10cENSG0000017353524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR020465  Tumour necrosis factor receptor 10
 IPR034024  Tumor necrosis factor receptor 10, N-terminal
 IPR034029  Tumour necrosis factor receptor 10A/B, death domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity NAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors NAS
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0036462 TRAIL-activated apoptotic signaling pathway IDA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway TAS
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005035 death receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0045569 TRAIL binding IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
Cell surface interactions at the vascular wall
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TP53 Regulates Transcription of Death Receptors and Ligands
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120889 O14763 / TNFRSF10B / TNF receptor superfamily member 10b  / reaction / complex
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000003402 CFLAR / O15519 / CASP8 and FADD like apoptosis regulator  / reaction / complex
 ENSG00000173530 Q9UBN6 / TNFRSF10D / TNF receptor superfamily member 10d  / complex / reaction
 ENSG00000104689 O00220 / TNFRSF10A / TNF receptor superfamily member 10a  / complex / reaction
 ENSG00000121858 P50591 / TNFSF10 / TNF superfamily member 10  / complex / reaction
 ENSG00000003400 CASP10 / Q92851 / caspase 10  / complex / reaction
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / reaction / complex






 

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