ENSG00000003402


Homo sapiens

Features
Gene ID: ENSG00000003402
  
Biological name :CFLAR
  
Synonyms : CASP8 and FADD like apoptosis regulator / CFLAR / O15519
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q33.1
Gene start: 201116104
Gene end: 201176687
  
Corresponding Affymetrix probe sets: 208485_x_at (Human Genome U133 Plus 2.0 Array)   209508_x_at (Human Genome U133 Plus 2.0 Array)   209939_x_at (Human Genome U133 Plus 2.0 Array)   210563_x_at (Human Genome U133 Plus 2.0 Array)   210564_x_at (Human Genome U133 Plus 2.0 Array)   211316_x_at (Human Genome U133 Plus 2.0 Array)   211317_s_at (Human Genome U133 Plus 2.0 Array)   211862_x_at (Human Genome U133 Plus 2.0 Array)   214486_x_at (Human Genome U133 Plus 2.0 Array)   214618_at (Human Genome U133 Plus 2.0 Array)   217654_at (Human Genome U133 Plus 2.0 Array)   224261_at (Human Genome U133 Plus 2.0 Array)   235427_at (Human Genome U133 Plus 2.0 Array)   237367_x_at (Human Genome U133 Plus 2.0 Array)   239629_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409570
Ensembl peptide - ENSP00000406775
Ensembl peptide - ENSP00000411535
Ensembl peptide - ENSP00000471805
Ensembl peptide - ENSP00000471749
Ensembl peptide - ENSP00000469917
Ensembl peptide - ENSP00000469608
Ensembl peptide - ENSP00000413270
Ensembl peptide - ENSP00000412882
Ensembl peptide - ENSP00000411897
Ensembl peptide - ENSP00000312455
Ensembl peptide - ENSP00000339326
Ensembl peptide - ENSP00000339335
Ensembl peptide - ENSP00000342809
Ensembl peptide - ENSP00000345807
Ensembl peptide - ENSP00000378580
Ensembl peptide - ENSP00000391029
Ensembl peptide - ENSP00000398551
Ensembl peptide - ENSP00000399420
NCBI entrez gene - 8837     See in Manteia.
OMIM - 603599
RefSeq - XM_017005198
RefSeq - NM_001127183
RefSeq - NM_001127184
RefSeq - NM_001202516
RefSeq - NM_001202517
RefSeq - NM_001202518
RefSeq - NM_001202519
RefSeq - NM_001308042
RefSeq - NM_001308043
RefSeq - NM_003879
RefSeq - XM_017005189
RefSeq - XM_017005190
RefSeq - XM_017005191
RefSeq - XM_017005192
RefSeq - XM_017005193
RefSeq - XM_017005194
RefSeq - XM_017005195
RefSeq - XM_017005196
RefSeq - XM_017005197
RefSeq Peptide - NP_001189448
RefSeq Peptide - NP_001294971
RefSeq Peptide - NP_001120655
RefSeq Peptide - NP_001120656
RefSeq Peptide - NP_001189445
RefSeq Peptide - NP_001189446
RefSeq Peptide - NP_001294972
RefSeq Peptide - NP_001338519
RefSeq Peptide - NP_001338520
RefSeq Peptide - NP_001338521
RefSeq Peptide - NP_001338522
RefSeq Peptide - NP_001338523
RefSeq Peptide - NP_003870
RefSeq Peptide - NP_001189447
swissprot - C9J408
swissprot - A0A024R3Y3
swissprot - E9PAP3
swissprot - C9JV51
swissprot - C9JSU3
swissprot - C9J4Q0
swissprot - O15519
swissprot - A0A0A0MR92
swissprot - A0A024R3Z7
swissprot - F8WBH9
swissprot - M0QY57
swissprot - M0QYM0
swissprot - M0R1A8
Ensembl - ENSG00000003402
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cflaraENSDARG00000055966Danio rerio
 cflarbENSDARG00000074802Danio rerio
 CFLARENSGALG00000008240Gallus gallus
 CflarENSMUSG00000026031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR029030  Caspase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0007519 skeletal muscle tissue development ISS
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014732 skeletal muscle atrophy ISS
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation ISS
 biological_processGO:0014866 skeletal myofibril assembly ISS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043403 skeletal muscle tissue regeneration ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0060544 regulation of necroptotic process IDA
 biological_processGO:0060546 negative regulation of necroptotic process IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0072126 positive regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 biological_processGO:1901740 negative regulation of myoblast fusion ISS
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1903055 positive regulation of extracellular matrix organization IEA
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1903944 negative regulation of hepatocyte apoptotic process IEA
 biological_processGO:1904036 negative regulation of epithelial cell apoptotic process IEA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031264 death-inducing signaling complex IDA
 cellular_componentGO:0031265 CD95 death-inducing signaling complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097342 ripoptosome IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008047 enzyme activator activity IDA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104689 O00220 / TNFRSF10A / TNF receptor superfamily member 10a  / reaction / complex
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / reaction / complex
 ENSG00000121858 P50591 / TNFSF10 / TNF superfamily member 10  / reaction / complex
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / reaction / complex
 ENSG00000120889 O14763 / TNFRSF10B / TNF receptor superfamily member 10b  / complex / reaction
 ENSG00000117560 FASLG / P48023 / Fas ligand  / complex / reaction
 ENSG00000026103 FAS / P25445 / Fas cell surface death receptor  / complex / reaction
 ENSG00000102871 TRADD / Q15628 / TNFRSF1A associated via death domain  / reaction / complex
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / complex / reaction






 

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