ENSGALG00000008240


Gallus gallus

Features
Gene ID: ENSGALG00000008240
  
Biological name :CFLAR
  
Synonyms : CASP8 and FADD-like apoptosis regulator / CFLAR
  
Possible biological names infered from orthology : CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519 / O35732
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 11453269
Gene end: 11472335
  
Corresponding Affymetrix probe sets: GgaAffx.5200.1.S1_at (Chicken Array)   GgaAffx.5200.2.S1_at (Chicken Array)   GgaAffx.5200.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013394
NCBI entrez gene - 424080     See in Manteia.
RefSeq - XM_015289425
RefSeq - NM_001202462
RefSeq - XM_015289423
RefSeq - XM_015289424
RefSeq - XM_015289422
RefSeq Peptide - NP_001189391
swissprot - E1C4U6
Ensembl - ENSGALG00000008240
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cflaraENSDARG00000055966Danio rerio
 cflarbENSDARG00000074802Danio rerio
 CFLARENSG00000003402Homo sapiens
 CflarENSMUSG00000026031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR029030  Caspase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0014732 skeletal muscle atrophy IEA
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IEA
 biological_processGO:0014866 skeletal myofibril assembly IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0060544 regulation of necroptotic process IEA
 biological_processGO:0060546 negative regulation of necroptotic process IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 biological_processGO:1901740 negative regulation of myoblast fusion IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031264 death-inducing signaling complex IEA
 cellular_componentGO:0097342 ripoptosome IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003076 FASLG / Fas ligand / Fasl* / P41047* / P48023* / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor lig...  / reaction / complex
 ENSGALG00000000452 TNFRSF10B / O14798* / Q9UBN6* / O00220* / O14763* / Q9QZM4* / TNFRSF10D* / TNFRSF10A* / TNFRSF10C* / TNF receptor superfamily member 10b* / TNF receptor superfamily member 10a* / TNF recept...  / reaction / complex
 ENSGALG00000007625 FADD / Fas associated via death domain / Q13158* / Q61160* / FAS-associated death domain protein *  / reaction / complex
 ENSGALG00000009179 TNFSF10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*  / reaction / complex
 ENSGALG00000012827 RIPK1 / receptor interacting serine/threonine kinase 1 / Q13546* / Q60855* / Receptor-interacting serine/threonine-protein kinase 1 *  / reaction / complex
 ENSGALG00000006351 FAS / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction






 

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