ENSGALG00000003076


Gallus gallus

Features
Gene ID: ENSGALG00000003076
  
Biological name :FASLG
  
Synonyms : FASLG / Fas ligand
  
Possible biological names infered from orthology : Fasl / P41047 / P48023 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble form ADAM10-processed FasL form FasL intracellular domain
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 4479414
Gene end: 4482429
  
Corresponding Affymetrix probe sets: GgaAffx.1941.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004854
NCBI entrez gene - 429064     See in Manteia.
RefSeq - NM_001031559
RefSeq - XM_015290324
RefSeq Peptide - NP_001026730
swissprot - Q5CAQ0
Ensembl - ENSGALG00000003076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 faslgENSDARG00000098913Danio rerio
 FASLGENSG00000117560Homo sapiens
 FaslENSMUSG00000000817Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNFSF15 / TNF superfamily member 15 / O95150* / tumor necrosis factor (ligand) superfamily, member 15*ENSGALG0000000717424


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0046666 retinal cell programmed cell death IEA
 biological_processGO:0070231 T cell apoptotic process IEA
 biological_processGO:0070266 necroptotic process IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097527 necroptotic signaling pathway IEA
 biological_processGO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
CASP8 activity is inhibited
TNFs bind their physiological receptors
Dimerization of procaspase-8
FasL/ CD95L signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008240 CFLAR / CASP8 and FADD-like apoptosis regulator / O15519* / O35732* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apopto...  / reaction / complex
 ENSGALG00000003076 FASLG / Fas ligand / Fasl* / P41047* / P48023* / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor lig...  / reaction / complex
 ENSGALG00000006106 TNFRSF6B / TNF receptor superfamily member 6b / O95407*  / complex / reaction
 ENSGALG00000007625 FADD / Fas associated via death domain / Q13158* / Q61160* / FAS-associated death domain protein *  / reaction / complex
 ENSGALG00000006351 FAS / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / reaction / complex






 

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