ENSMUSG00000000817


Mus musculus

Features
Gene ID: ENSMUSG00000000817
  
Biological name :Fasl
  
Synonyms : Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble form ADAM10-processed FasL form FasL intracellular domain
  
Possible biological names infered from orthology : FASLG / Fas ligand / P48023
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.1
Gene start: 161780689
Gene end: 161788495
  
Corresponding Affymetrix probe sets: 10359434 (MoGene1.0st)   1418803_a_at (Mouse Genome 430 2.0 Array)   1449235_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000834
Ensembl peptide - ENSMUSP00000141422
NCBI entrez gene - 14103     See in Manteia.
MGI - MGI:99255
RefSeq - NM_010177
RefSeq - NM_001205243
RefSeq Peptide - NP_001192172
RefSeq Peptide - NP_034307
swissprot - P41047
swissprot - Q544E9
Ensembl - ENSMUSG00000000817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 faslgENSDARG00000098913Danio rerio
 FASLGENSGALG00000003076Gallus gallus
 FASLGENSG00000117560Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnfsf15 / tumor necrosis factor (ligand) superfamily, member 15 / O95150* / TNF superfamily member 15*ENSMUSG0000005039522
Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, so...ENSMUSG0000000582421
Tnf / P06804 / tumor necrosis factor / P01375*ENSMUSG0000002440120
Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*ENSMUSG0000002440218


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site
 IPR028326  Tumor necrosis factor ligand superfamily member 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0006925 inflammatory cell apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0030644 cellular chloride ion homeostasis IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0046666 retinal cell programmed cell death IMP
 biological_processGO:0048388 endosomal lumen acidification IEA
 biological_processGO:0070231 T cell apoptotic process ISO
 biological_processGO:0070266 necroptotic process ISO
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0097190 apoptotic signaling pathway ISO
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:0097527 necroptotic signaling pathway ISO
 biological_processGO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum ISO
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043202 lysosomal lumen IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0060205 cytoplasmic vesicle lumen IEA
 cellular_componentGO:0070062 extracellular exosome ISO
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
FasL/ CD95L signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Fasltm1.1Bksa/Fasltm1.1Bksa
Genetic Background: involves: 129

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Faslgld/Faslgld
Genetic Background: B6.C3-Faslgld

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Fasltm1.1Bksa/Fasltm1.1Bksa
Genetic Background: involves: 129

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Faslgld/Faslgld
Genetic Background: B6.C3-Faslgld

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Faslgld/Faslgld
Genetic Background: B6.C3-Faslgld

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc45a2uw-9Btlr/Slc45a2uw-9Btlr
Genetic Background: C57BL/6J-Slc45a2uw-9Btlr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd22m4Btlr/Cd22m4Btlr
Genetic Background: C57BL/6J-Cd22m4Btlr

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0001863 vascular inflammation "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Faslgld/Faslgld
Genetic Background: B6.C3-Faslgld

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Fasltm1.1Cgm/Fasltm1.1Cgm
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Faslgld/Faslgld
Genetic Background: B6.C3-Faslgld

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Faslgld/Faslgld
Genetic Background: B6.C3-Faslgld

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ

Allelic Composition: Fasltm1.1Bksa/Fasltm1.1Bksa
Genetic Background: involves: 129

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Faslgld/Faslgld
Genetic Background: B6.C3-Faslgld

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fasltm1.1Cgm/Fasltm1.1Cgm
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fasltm1.1Cgm/Fasltm1.1Cgm
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Faslgld/Faslgld
Genetic Background: B6.C3-Faslgld

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Keny/Il10+,Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fasltm2.1Bksa/Fasltm2.1Bksa
Genetic Background: D2.129-Fasltm2.1Bksa

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Keny/Il10+,Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic Background: involves: 129 * C57BL/6

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Keny/Il10+,Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fasltm1.1Bksa/Fasltm1.1Bksa
Genetic Background: involves: 129

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Keny/Il10+,Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fasltm2.1Bksa/Fasltm2.1Bksa
Genetic Background: D2.129-Fasltm2.1Bksa

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fasltm1.1Cgm/Fasltm1.1Cgm
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Fasltm1.1Cgm/Fasltm1.1Cgm
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Fasltm1.1Ast/Fasltm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Fasldel1Hong/Fasldel1Hong
Genetic Background: either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Cd22m4Btlr/Cd22m4Btlr
Genetic Background: C57BL/6J-Cd22m4Btlr

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Il10tm1Keny/Il10+,Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / reaction / complex
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / reaction / complex
 ENSMUSG00000000817 Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...  / reaction / complex
 ENSMUSG00000024778 Fas / P25446 / Tumor necrosis factor receptor superfamily member 6 / P25445* / Fas cell surface death receptor*  / complex / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction / complex






 

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