ENSMUSG00000024778


Mus musculus

Features
Gene ID: ENSMUSG00000024778
  
Biological name :Fas
  
Synonyms : Fas / P25446 / Tumor necrosis factor receptor superfamily member 6
  
Possible biological names infered from orthology : Fas cell surface death receptor / P25445
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 34290659
Gene end: 34327770
  
Corresponding Affymetrix probe sets: 10462603 (MoGene1.0st)   1460251_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025691
Ensembl peptide - ENSMUSP00000108091
NCBI entrez gene - 14102     See in Manteia.
MGI - MGI:95484
RefSeq - XM_011247141
RefSeq - NM_001146708
RefSeq - NM_007987
RefSeq Peptide - NP_032013
RefSeq Peptide - NP_001140180
swissprot - P25446
swissprot - Q8C350
Ensembl - ENSMUSG00000024778
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fasENSDARG00000043586Danio rerio
 FASENSGALG00000006351Gallus gallus
 FASENSG00000026103Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR008063  Fas receptor
 IPR011029  Death-like domain superfamily
 IPR033998  Fas receptor, death domain
 IPR033999  Fas receptor, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002377 immunoglobulin production IMP
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006924 activation-induced cell death of T cells IMP
 biological_processGO:0006925 inflammatory cell apoptotic process IMP
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0010467 gene expression IMP
 biological_processGO:0019724 B cell mediated immunity IMP
 biological_processGO:0032464 positive regulation of protein homooligomerization IDA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032872 regulation of stress-activated MAPK cascade ISO
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034198 cellular response to amino acid starvation ISO
 biological_processGO:0036337 Fas signaling pathway ISO
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0045619 regulation of lymphocyte differentiation IMP
 biological_processGO:0045637 regulation of myeloid cell differentiation IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0050869 negative regulation of B cell activation IMP
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051384 response to glucocorticoid IMP
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0070230 positive regulation of lymphocyte apoptotic process IDA
 biological_processGO:0071285 cellular response to lithium ion IMP
 biological_processGO:0071455 cellular response to hyperoxia ISO
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IC
 biological_processGO:0097049 motor neuron apoptotic process IMP
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:0097284 hepatocyte apoptotic process IGI
 biological_processGO:0097527 necroptotic signaling pathway ISO
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway ISO
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031264 death-inducing signaling complex ISO
 cellular_componentGO:0031265 CD95 death-inducing signaling complex IDA
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043120 tumor necrosis factor binding IBA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
FasL/ CD95L signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Fasm1Btlr/Fasm1Btlr
Genetic Background: C57BL/6J-Fasm1Btlr

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Acetm3Unc/Acetm3Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Faslpr/Faslpr,Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Hprttm2(AGT)Sig/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Cd19tm1(cre)Cgn Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Fastm1.1Cgn/Fastm1.1Cgn
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Fastm1.1Cgn
Genetic Background: involves: C57BL/6 * MRL

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Hprttm2(AGT)Sig/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Fastm1Dlo/Fastm1Dlo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: atms/atms,Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Mx1-cre)1Cgn

Allelic Composition: Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * MRL

Allelic Composition: Fastm1.1Cgn/Fastm1.1Cgn
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Fastm1.1Cgn
Genetic Background: involves: C57BL/6 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background: Not Specified

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: Faslpr/Faslpr,Il2ratm1Dw/Il2ratm1Dw,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2ratm1Dw Faslpr Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0000701 abnormal lymph node size "deviation from the normal lymph node size " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B10.129P2(B6)-Il10tm1Cgn/J

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Fastm1Dlo/Fastm1Dlo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: atms/atms,Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Mx1-cre)1Cgn

Allelic Composition: Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * MRL

Allelic Composition: Fastm1.1Cgn/Fastm1.1Cgn
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Fastm1.1Cgn
Genetic Background: involves: C57BL/6 * MRL

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0001017 abnormal stellate ganglion morphology "malformation or absence of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

 MP:0001220 epidermal necrosis "pathological cell death in the epidermal layer of the skin, usually due to irreversible damage" [J:65146]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

 MP:0001346 abnormal lacrimal gland morphology "malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad1tm1Sor/Smad1tm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0001830 decreased activated T cell number "reduced numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Faslpr/Fas+,Tg(TcraTcrb)1100Mjb/?
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0001863 vascular inflammation "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002148 immune system: hypersensitivity "immune response that results in tissue injury" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002163 abnormal gland morphology "abnormal development of any glandular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fasm1Btlr/Fasm1Btlr
Genetic Background: C57BL/6J-Fasm1Btlr

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002224 abnormal spleen size "deviation from the normal spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B10.129P2(B6)-Il10tm1Cgn/J

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background: Not Specified

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: MRL/Mp

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Dsg4hage/Dsg4hage,Faslpr/Faslpr,X/Yaa
Genetic Background: EOD-Dsg4hage

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Fastm1Dlo/Fastm1Dlo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background: Not Specified

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background: Not Specified

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background: Not Specified

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0002533 type III hypersensitivity reaction "tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: MRL.Cg-Il4tm1Cgn Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

 MP:0003504 thyroid inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0003670 dilated glomerular capsule "an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0003793 abnormal submandibular gland morphology "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0003946 renal necrosis "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk,Tg(INS-Il10)#Sar/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * NOD

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0004367 abnormal strial intermediate cells "any structural abnormality in the melanocytes known to migrate from the neural crest during ontogeny to become located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0004368 abnormal stria vascularis vasculature "any structural anomaly of the blood vessels supplying the stria vascularis in the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

 MP:0004481 abnormal conjunctival epithelium "any structural anomaly in the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: Faslpr/Faslpr,Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
Genetic Background: MRL.Cg-Faslpr Igh-Jtm2(3H9-VDJ*)Mwg

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Cd40lgtm1Flv/Y,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Cd40lgtm1Flv/Cd40lgtm1Flv,Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Cgn/Fastm1Cgn
Genetic Background: B6.Cg-Cd19tm1(cre)Cgn Fastm1Cgn

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Cd19tm1(cre)Cgn Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(GZMB-cre)1Jcb/?
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background: Not Specified

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0004795 decreased anti-nuclear antigen antibody level "reduced level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0004797 increased anti-erythrocyte antigen antibody level "elevated level of antibodies to erythrocyte antigen present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0004798 decreased anti-double stranded DNA antibody level "reduced level of antibodies to double stranded DNA present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Mogtm1(cre)Gkl/Mog+,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acvrl1tm1Spo/Acvrl1tm1Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Faslpr/Faslpr,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Faslpr Tg(INS-Il10)#Sar

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Faslpr Tg(INS-Il10)#Sar

Allelic Composition: Faslpr/Faslpr,Tg(Ins2-Fasl)24Ach/0
Genetic Background: NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach

Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0005002 abnormal T cell clonal deletion "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vsx2or-J/Vsx2or-J,Modor3CASA/Rk/?
Genetic Background: involves: 129S1/Sv * CASA/Rk

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fastm1Osa/Fastm1Osa,Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * MRL

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(GZMB-cre)1Jcb/?
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0005265 abnormal blood urea nitrogen level "aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Crr/C3tm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0005614 decreased susceptibility to type III hypersensitivity reaction "less likelihood of or resistance to developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0005615 increased susceptibility to type III hypersensitivity reaction "greater likelihood of developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background: Not Specified

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0006099 thin granule layer "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: atms/atms,Faslpr/?
Genetic Background: MRL/Mp-Faslpr atms

 MP:0006315 abnormal kidney protein excretion "anomaly in the amount of protein eliminated by the kidneys" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72c/Cd72c,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Fasm1Btlr/Fasm1Btlr
Genetic Background: C57BL/6J-Fasm1Btlr

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Keny/Il10+,Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic Background: involves: 129 * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1tm1Mak
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Irf1tm1Mak/Irf1+
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Faslpr/Faslpr,Tg(CD2-Foxj1)#Stlp/0
Genetic Background: MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp

Allelic Composition: Fasm1Btlr/Fasm1Btlr
Genetic Background: C57BL/6J-Fasm1Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Fasm1Btlr/Fasm1Btlr
Genetic Background: C57BL/6J-Fasm1Btlr

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Lck-cre)I57Jxm/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Lck-cre)I57Jxm

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Ach/Fastm1Ach,Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background: Not Specified

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008180 abnormal marginal zone B cell morphology "any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr,Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
Genetic Background: MRL.Cg-Faslpr Igh-Jtm2(3H9-VDJ*)Mwg

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0008206 increased B-2 cell number "greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/Mp

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * MRL

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

 MP:0008350 increased gamma-delta intraepithelial T cell number "greater number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Faslpr/Faslpr,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * MRL

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd180tm1Kmiy/Cd180tm1Kmiy,Faslpr/Faslpr
Genetic Background: MRL.Cg-Cd180tm1Kmiy Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: MRL.Cg-Ifngr1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

Allelic Composition: Faslpr/Faslpr,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: MRL.Cg-Ifnar1tm1Agt Faslpr

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0008626 increased circulating interleukin-5 level "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0008766 abnormal B cell receptor editing "any anomaly in the process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor" [GO:0002452, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr,Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
Genetic Background: MRL.Cg-Faslpr Igh-Jtm2(3H9-VDJ*)Mwg

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0008879 submandibular gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: MRL.Cg-Il4tm1Cgn Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0008978 abnormal vagina weight "anomaly in the weight of the female reproductive canal located between the uterus and the vulva" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: MRL/Mp

 MP:0010065 decreased circulating creatine level "reduction in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0010922 alveolitis "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: MRL/Mp

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Faslpr/Faslpr
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0011445 abnormal renal protein reabsorption "any anomaly in the process in which proteins are taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0097017]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0011483 renal glomerular synechia "presence of adhesions (synechiae) between the Bowman s capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman s capsule" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0011567 increased renal glomerulus lobularity "distortion of the renal glomerular architecture usually accompanied by increased mesangial cell proliferation and following crowding of the proliferated cells towards the axis of the capillary loops and peripheral recanalization, giving the glomerular tuft a lobular or hypersegmented appearance" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0011742 decreased urine nitrite level "lower than normal amount of nitrite (NO2-) in the urine; suggestive of impaired nitric oxide (NO) release" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C3H * MRL/Mp

 MP:0012433 decreased ovarian tumor incidence "less than the expected number of neoplams in the ovary occurring in a specific population in a given time period" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0013452 increased lacrimal gland apoptosis " increase in the number of cells of the lacrimal gland undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

 MP:0013455 lacrimal gland atrophy "acquired diminution of the size of any of the paired glands that secrete the aqueous layer of the tear film, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr

 MP:0013585 thymus cortex atrophy "acquired diminution of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Faslpr/Faslpr,Selptm1Bay/Selptm1Bay
Genetic Background: MRL.Cg-Selptm1Bay Faslpr

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: MRL.Cg-Tnfrsf9tm1Byk Faslpr

Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL.Cg-Irf1tm1Mak Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Cd72tm1Tsub/Cd72tm1Tsub,Faslpr/Faslpr
Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000817 Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...  / complex / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction / complex
 ENSMUSG00000024778 Fas / P25446 / Tumor necrosis factor receptor superfamily member 6 / P25445* / Fas cell surface death receptor*  / reaction / complex
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / complex / reaction






 

1 s.

 
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