ENSMUSG00000031077


Mus musculus

Features
Gene ID: ENSMUSG00000031077
  
Biological name :Fadd
  
Synonyms : Fadd / FAS-associated death domain protein / Q61160
  
Possible biological names infered from orthology : Fas associated via death domain / Q13158
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 144577318
Gene end: 144582463
  
Corresponding Affymetrix probe sets: 10569611 (MoGene1.0st)   1416888_at (Mouse Genome 430 2.0 Array)   1446499_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033394
NCBI entrez gene - 14082     See in Manteia.
MGI - MGI:109324
RefSeq - NM_010175
RefSeq Peptide - NP_034305
swissprot - Q61160
Ensembl - ENSMUSG00000031077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 faddENSDARG00000103021Danio rerio
 FADDENSGALG00000007625Gallus gallus
 FADDENSG00000168040Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily
 IPR016729  FADD


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002821 positive regulation of adaptive immune response IMP
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030217 T cell differentiation TAS
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0036462 TRAIL-activated apoptotic signaling pathway IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048535 lymph node development IGI
 biological_processGO:0048536 spleen development IGI
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0048738 cardiac muscle tissue development TAS
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0060544 regulation of necroptotic process IEA
 biological_processGO:0060546 negative regulation of necroptotic process IGI
 biological_processGO:0070236 negative regulation of activation-induced cell death of T cells IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0097049 motor neuron apoptotic process IMP
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IEA
 biological_processGO:0097527 necroptotic signaling pathway IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
 biological_processGO:2000454 positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation IMP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031264 death-inducing signaling complex IEA
 cellular_componentGO:0031265 CD95 death-inducing signaling complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097342 ripoptosome IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IEA
 molecular_functionGO:0033612 receptor serine/threonine kinase binding IEA
 molecular_functionGO:0035877 death effector domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0089720 caspase binding IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0000494 abnormal cecum morphology "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp4mdig-2J/Lrp4mdig-2J
Genetic Background: involves: C3H/HeSnJ * SB/LeJ

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp4mdig-2J/Lrp4mdig-2J
Genetic Background: involves: C3H/HeSnJ * SB/LeJ

 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
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Allelic Composition: Lrp4mdig-2J/Lrp4mdig-2J
Genetic Background: involves: C3H/HeSnJ * SB/LeJ

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd)33Wnt/0,Tg(Lck-cre)I57Jxm/0,Tg(Tcra2C,Tcrb2C)1Dlo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001830 decreased activated T cell number "reduced numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grhl2m1Nisw/Grhl2m1Nisw
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Tnftm1Gkl/Tnftm1Gkl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil1-cre)997Gum

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Faddtm2.1Wnt/Faddtm2.1Wnt,Tg(Cd4-cre)1Cwi/?
Genetic Background: B6.Cg-Faddtm2.1Wnt Tg(Cd4-cre)1Cwi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6 * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

Allelic Composition: Faddtm2.1Wnt/Faddtm2.1Wnt,Tg(Cd4-cre)1Cwi/?
Genetic Background: B6.Cg-Faddtm2.1Wnt Tg(Cd4-cre)1Cwi

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faddtm2.1Wnt/Faddtm2.1Wnt,Tg(Cd4-cre)1Cwi/?
Genetic Background: B6.Cg-Faddtm2.1Wnt Tg(Cd4-cre)1Cwi

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd)33Wnt/0,Tg(Lck-cre)I57Jxm/0,Tg(Tcra2C,Tcrb2C)1Dlo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faddtm2.1Wnt/Faddtm2.1Wnt,Tg(Cd4-cre)1Cwi/?
Genetic Background: B6.Cg-Faddtm2.1Wnt Tg(Cd4-cre)1Cwi

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Faddtm1Wnt/Faddtm1Wnt,Tg(Fadd/EGFP)#Jizh/?,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009258 abnormal thymocyte apoptosis "change in the timing or the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893]
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Allelic Composition: Faddtm2.1Wnt/Faddtm2.1Wnt,Tg(Cd4-cre)1Cwi/?
Genetic Background: B6.Cg-Faddtm2.1Wnt Tg(Cd4-cre)1Cwi

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Faddtm1Mpa/Faddtm1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Tnftm1Gkl/Tnftm1Gkl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil1-cre)997Gum

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Myd88tm1Aki/Myd88tm1Aki,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Myd88tm1Aki Tg(Vil1-cre)997Gum

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0010205 abnormal oligodendrocyte apoptosis "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Tbx10Dc/Tbx10Dc
Genetic Background: DC/LeJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Faddtm1Mpa/Faddtm1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Tnftm1Gkl/Tnftm1Gkl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil1-cre)997Gum

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Myd88tm1Aki/Myd88tm1Aki,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Myd88tm1Aki Tg(Vil1-cre)997Gum

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000817 Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...  / complex / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000024778 Fas / P25446 / Tumor necrosis factor receptor superfamily member 6 / P25445* / Fas cell surface death receptor*  / reaction / complex
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000022074 Q9QZM4 / Tnfrsf10b / Tumor necrosis factor receptor superfamily member 10B / O14798* / Q9UBN6* / O14763* / O00220* / TNFRSF10D* / TNFRSF10A* / TNFRSF10C* / TNF receptor superfamily member ...  / reaction / complex
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / reaction / complex
 ENSMUSG00000031887 Tradd / Q3U0V2 / TNFRSF1A-associated via death domain / Q15628*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / reaction / complex
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000039304 P50592 / Tnfsf10 / tumor necrosis factor (ligand) superfamily, member 10 / P50591* / TNF superfamily member 10*  / complex / reaction






 

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