ENSMUSG00000039304


Mus musculus

Features
Gene ID: ENSMUSG00000039304
  
Biological name :Tnfsf10
  
Synonyms : P50592 / Tnfsf10 / tumor necrosis factor (ligand) superfamily, member 10
  
Possible biological names infered from orthology : P50591 / TNF superfamily member 10
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 27317028
Gene end: 27342427
  
Corresponding Affymetrix probe sets: 10491091 (MoGene1.0st)   1420412_at (Mouse Genome 430 2.0 Array)   1439680_at (Mouse Genome 430 2.0 Array)   1459913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040271
Ensembl peptide - ENSMUSP00000133917
NCBI entrez gene - 22035     See in Manteia.
MGI - MGI:107414
RefSeq - NM_009425
RefSeq Peptide - NP_033451
swissprot - G3UY25
swissprot - P50592
swissprot - Q3U5H0
Ensembl - ENSMUSG00000039304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfsf10ENSDARG00000057241Danio rerio
 TNFSF10ENSGALG00000009179Gallus gallus
 P50591ENSG00000121858Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35235 / Tnfsf11 / tumor necrosis factor (ligand) superfamily, member 11 / O14788* / TNF superfamily member 11*ENSMUSG0000002201522


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR017355  Tumour necrosis factor ligand 10/11
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
Genetic Background: B6.129-Tnfsf10tm1Mjs

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rictortm1.2Mgn/Rictortm1.3Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction / complex
 ENSMUSG00000022074 Q9QZM4 / Tnfrsf10b / Tumor necrosis factor receptor superfamily member 10B / O14798* / Q9UBN6* / O14763* / O00220* / TNFRSF10D* / TNFRSF10A* / TNFRSF10C* / TNF receptor superfamily member ...  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSMUSG00000039304 P50592 / Tnfsf10 / tumor necrosis factor (ligand) superfamily, member 10 / P50591* / TNF superfamily member 10*  / complex / reaction
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / complex / reaction






 

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