ENSMUSG00000026031


Mus musculus

Features
Gene ID: ENSMUSG00000026031
  
Biological name :Cflar
  
Synonyms : CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / Cflar / O35732
  
Possible biological names infered from orthology : CASP8 and FADD like apoptosis regulator / O15519
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.3
Gene start: 58711508
Gene end: 58758884
  
Corresponding Affymetrix probe sets: 10346551 (MoGene1.0st)   10346562 (MoGene1.0st)   10497931 (MoGene1.0st)   1424996_at (Mouse Genome 430 2.0 Array)   1425686_at (Mouse Genome 430 2.0 Array)   1425687_at (Mouse Genome 430 2.0 Array)   1449317_at (Mouse Genome 430 2.0 Array)   1453482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065107
Ensembl peptide - ENSMUSP00000095329
Ensembl peptide - ENSMUSP00000109948
Ensembl peptide - ENSMUSP00000109952
NCBI entrez gene - 12633     See in Manteia.
MGI - MGI:1336166
RefSeq - XM_017313595
RefSeq - NM_001289704
RefSeq - NM_001293804
RefSeq - NM_001293805
RefSeq - NM_009805
RefSeq - NM_207653
RefSeq - XM_006495635
RefSeq - XM_011238420
RefSeq - XM_011238421
RefSeq - XM_011238422
RefSeq - XM_011238423
RefSeq - XM_017313559
RefSeq Peptide - NP_001280734
RefSeq Peptide - NP_033935
RefSeq Peptide - NP_997536
RefSeq Peptide - NP_001276633
RefSeq Peptide - NP_001280733
swissprot - O35732
swissprot - Q812G4
swissprot - A0A2C9F2D9
swissprot - Q5U4G3
Ensembl - ENSMUSG00000026031
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cflaraENSDARG00000055966Danio rerio
 cflarbENSDARG00000074802Danio rerio
 CFLARENSGALG00000008240Gallus gallus
 CFLARENSG00000003402Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR029030  Caspase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014732 skeletal muscle atrophy IMP
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IMP
 biological_processGO:0014866 skeletal myofibril assembly IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043403 skeletal muscle tissue regeneration IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0060544 regulation of necroptotic process ISO
 biological_processGO:0060546 negative regulation of necroptotic process IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0072126 positive regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 biological_processGO:1901740 negative regulation of myoblast fusion IMP
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
 biological_processGO:1903055 positive regulation of extracellular matrix organization IEA
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1903944 negative regulation of hepatocyte apoptotic process IEA
 biological_processGO:1904036 negative regulation of epithelial cell apoptotic process IEA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0031264 death-inducing signaling complex ISO
 cellular_componentGO:0031265 CD95 death-inducing signaling complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097342 ripoptosome ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008047 enzyme activator activity ISO
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016504 peptidase activator activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008073 abnormal CD4-positive T cell number "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008077 abnormal CD8-positive T cell number "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: NsdhlStr-1Or/NsdhlStr-1Or
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: NsdhlStr-1Or/NsdhlStr-1Or
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009625 abnormal abdominal lymph node morphology 
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd,Tnfrsf25tm1Lex/Tnfrsf25tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000817 Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...  / reaction / complex
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000024778 Fas / P25446 / Tumor necrosis factor receptor superfamily member 6 / P25445* / Fas cell surface death receptor*  / reaction / complex
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / reaction / complex
 ENSMUSG00000022074 Q9QZM4 / Tnfrsf10b / Tumor necrosis factor receptor superfamily member 10B / O14798* / Q9UBN6* / O14763* / O00220* / TNFRSF10D* / TNFRSF10A* / TNFRSF10C* / TNF receptor superfamily member ...  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / reaction / complex
 ENSMUSG00000031887 Tradd / Q3U0V2 / TNFRSF1A-associated via death domain / Q15628*  / complex / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / reaction / complex
 ENSMUSG00000039304 P50592 / Tnfsf10 / tumor necrosis factor (ligand) superfamily, member 10 / P50591* / TNF superfamily member 10*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr