ENSDARG00000055966


Danio rerio

Features
Gene ID: ENSDARG00000055966
  
Biological name :cflara
  
Synonyms : CASP8 and FADD-like apoptosis regulator a / cflara
  
Possible biological names infered from orthology : CASP8 and FADD like apoptosis regulator / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / CFLAR / O15519 / O35732
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 30332959
Gene end: 30341431
  
Corresponding Affymetrix probe sets: DrAffx.1.48.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000072840
NCBI entrez gene - 373114     See in Manteia.
RefSeq - NM_001313772
RefSeq Peptide - NP_001300701
swissprot - F1R706
ZFIN ID - ZDB-GENE-030826-3
Ensembl - ENSDARG00000055966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CFLARENSGALG00000008240Gallus gallus
 CFLARENSG00000003402Homo sapiens
 CflarENSMUSG00000026031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cflarb / CASP8 and FADD-like apoptosis regulator b / CFLAR* / O15519* / CASP8 and FADD like apoptosis regulator*ENSDARG0000007480216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR029030  Caspase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004392 hdr / hematopoietic death receptor / Q9QZM4* / Q9UBN6* / O00220* / O14763* / O14798* / TNFRSF10D* / TNFRSF10C* / TNFRSF10B* / TNFRSF10A* / TNF receptor superfamily member 10a* / TNF recepto...  / reaction / complex
 ENSDARG00000036057 tradd / Q9I9N5 / tnfrsf1a-associated via death domain / Q15628* / Q3U0V2*  / reaction / complex
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / reaction / complex
 ENSDARG00000057241 tnfsf10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*  / reaction / complex
 ENSDARG00000098913 faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*  / reaction / complex
 ENSDARG00000043586 fas / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction






 

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