ENSMUSG00000026029


Mus musculus

Features
Gene ID: ENSMUSG00000026029
  
Biological name :Casp8
  
Synonyms : Casp8 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / O89110
  
Possible biological names infered from orthology : caspase 8 / Q14790
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.3
Gene start: 58795374
Gene end: 58847503
  
Corresponding Affymetrix probe sets: 10346564 (MoGene1.0st)   1424552_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027189
Ensembl peptide - ENSMUSP00000127375
Ensembl peptide - ENSMUSP00000140335
Ensembl peptide - ENSMUSP00000140546
NCBI entrez gene - 12370     See in Manteia.
MGI - MGI:1261423
RefSeq - XM_006495634
RefSeq - NM_001080126
RefSeq - NM_001277926
RefSeq - NM_009812
RefSeq Peptide - NP_001073595
RefSeq Peptide - NP_001264855
RefSeq Peptide - NP_033942
swissprot - O89110
swissprot - Q3U607
swissprot - A0A087WQT6
Ensembl - ENSMUSG00000026029
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp8ENSDARG00000058325Danio rerio
 CASP8ENSGALG00000008355Gallus gallus
 CASP8ENSG00000064012Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*ENSMUSG0000002891422
Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*ENSMUSG0000002507621
Casp2 / P29594 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P42575* / caspase 2*ENSMUSG0000002986320
Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*ENSMUSG0000002799719
Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*ENSMUSG0000003162819
Casp14 / O89094 / Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form / P31...ENSMUSG0000000535513
Casp16-ps / caspase 16, apoptosis-related cysteine peptidase, pseudogeneENSMUSG000000678829


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR033170  Caspase-8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:0030225 macrophage differentiation TAS
 biological_processGO:0034612 response to tumor necrosis factor ISO
 biological_processGO:0036462 TRAIL-activated apoptotic signaling pathway ISO
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0045651 positive regulation of macrophage differentiation ISO
 biological_processGO:0045862 positive regulation of proteolysis ISO
 biological_processGO:0048738 cardiac muscle tissue development TAS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process ISO
 biological_processGO:0060546 negative regulation of necroptotic process IGI
 biological_processGO:0070243 regulation of thymocyte apoptotic process IGI
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0097190 apoptotic signaling pathway ISO
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:0097194 execution phase of apoptosis ISS
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity ISO
 biological_processGO:0097284 hepatocyte apoptotic process IMP
 biological_processGO:2001233 regulation of apoptotic signaling pathway IGI
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030690 Noc1p-Noc2p complex IMP
 cellular_componentGO:0031264 death-inducing signaling complex ISO
 cellular_componentGO:0031265 CD95 death-inducing signaling complex ISO
 cellular_componentGO:0097342 ripoptosome ISS
 molecular_functionGO:0004175 endopeptidase activity IMP
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0035877 death effector domain binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0097110 scaffold protein binding ISO
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process ISO
 molecular_functionGO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Casp8tm1.1Vmd/Casp8tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Casp8tm1.1Vmd/Casp8tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz
Genetic Background: involves: 129P2/OlaHsd

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N * ICR

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

Allelic Composition: Casp8tm1.1Yuan/Casp8tm1.1Yuan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Fsttm1Zuk/Fsttm1Zuk,Wfikkn1tm1.1Sjl/Wfikkn1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N * ICR

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

Allelic Composition: Casp8tm1.1Yuan/Casp8tm1.1Yuan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz
Genetic Background: involves: 129P2/OlaHsd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1wobl/Grm1wobl
Genetic Background: C57BL/6Apb-Grm1wobl/Apb

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0002220 large lymphoid organs "increased size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dusp6tm1Sms/Dusp6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Casp8tm1.1Vmd/Casp8tm1.1Vmd,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8m1Btlr/Casp8m1Btlr
Genetic Background: C57BL/6J-Casp8m1Btlr

 MP:0005083 abnormal biliary tract morphology "anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N * ICR

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N * ICR

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

Allelic Composition: Casp8tm1.1Yuan/Casp8tm1.1Yuan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8m1Btlr/Casp8m1Btlr
Genetic Background: C57BL/6J-Casp8m1Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8m1Btlr/Casp8m1Btlr
Genetic Background: C57BL/6J-Casp8m1Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008113 abnormal macrophage differentiation "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009631 enlarged axillary lymph nodes "increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

 MP:0009795 epidermal spongiosis "intercellular edema within the epidermis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Casp8m1Btlr/Casp8m1Btlr
Genetic Background: C57BL/6J-Casp8m1Btlr

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Tg(KRT14-cre)1Efu/0
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Casp8tm1.1Yuan/Casp8tm1.1Yuan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Casp8tm1.1Vmd/Casp8tm1.1Vmd
Genetic Background: involves: C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Casp8tm1.1Vmd/Casp8+,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: C57BL/6N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
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Allelic Composition: Casp8tm1.1Raz/Casp8tm1.1Raz,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Casp8m1Btlr/Casp8m1Btlr
Genetic Background: C57BL/6J-Casp8m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000817 Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...  / complex / reaction
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / complex / reaction
 ENSMUSG00000031887 Tradd / Q3U0V2 / TNFRSF1A-associated via death domain / Q15628*  / complex / reaction
 ENSMUSG00000022565 Plec / Q9QXS1 / plectin / Q15149*  / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000024778 Fas / P25446 / Tumor necrosis factor receptor superfamily member 6 / P25445* / Fas cell surface death receptor*  / complex / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / reaction / complex
 ENSMUSG00000022074 Q9QZM4 / Tnfrsf10b / Tumor necrosis factor receptor superfamily member 10B / O14798* / Q9UBN6* / O14763* / O00220* / TNFRSF10D* / TNFRSF10A* / TNFRSF10C* / TNF receptor superfamily member ...  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000030793 Pycard / Q9EPB4 / PYD and CARD domain containing / PYDC1* / Q9ULZ3* / Q8WXC3* / pyrin domain containing 1*  / reaction / complex
 ENSMUSG00000026728 Vim / P20152 / vimentin / P08670*  / reaction
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / reaction
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSMUSG00000039304 P50592 / Tnfsf10 / tumor necrosis factor (ligand) superfamily, member 10 / P50591* / TNF superfamily member 10*  / reaction / complex
 ENSMUSG00000002015 Bcap31 / Q61335 / B-cell receptor-associated protein 31 / P51572*  / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / reaction / complex
 ENSMUSG00000038058 Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*  / reaction / complex






 

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