ENSMUSG00000022565


Mus musculus

Features
Gene ID: ENSMUSG00000022565
  
Biological name :Plec
  
Synonyms : Plec / plectin / Q9QXS1
  
Possible biological names infered from orthology : Q15149
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76170974
Gene end: 76232574
  
Corresponding Affymetrix probe sets: 10429802 (MoGene1.0st)   1419835_s_at (Mouse Genome 430 2.0 Array)   1434610_at (Mouse Genome 430 2.0 Array)   1437554_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126936
Ensembl peptide - ENSMUSP00000126912
Ensembl peptide - ENSMUSP00000127253
Ensembl peptide - ENSMUSP00000131946
Ensembl peptide - ENSMUSP00000130948
Ensembl peptide - ENSMUSP00000130915
Ensembl peptide - ENSMUSP00000129543
Ensembl peptide - ENSMUSP00000127867
Ensembl peptide - ENSMUSP00000127261
Ensembl peptide - ENSMUSP00000023226
Ensembl peptide - ENSMUSP00000057158
Ensembl peptide - ENSMUSP00000071765
Ensembl peptide - ENSMUSP00000072478
Ensembl peptide - ENSMUSP00000073124
Ensembl peptide - ENSMUSP00000074383
Ensembl peptide - ENSMUSP00000075772
Ensembl peptide - ENSMUSP00000079668
Ensembl peptide - ENSMUSP00000087037
Ensembl peptide - ENSMUSP00000126068
Ensembl peptide - ENSMUSP00000126526
NCBI entrez gene - 18810     See in Manteia.
MGI - MGI:1277961
RefSeq - NM_201387
RefSeq - NM_001163540
RefSeq - NM_001163542
RefSeq - NM_001163549
RefSeq - NM_001164203
RefSeq - NM_011117
RefSeq - NM_201385
RefSeq - NM_201386
RefSeq - NM_201388
RefSeq - NM_201389
RefSeq - NM_201390
RefSeq - NM_201391
RefSeq - NM_201392
RefSeq - NM_201393
RefSeq - NM_201394
RefSeq Peptide - NP_958791
RefSeq Peptide - NP_001157012
RefSeq Peptide - NP_001157021
RefSeq Peptide - NP_001157675
RefSeq Peptide - NP_035247
RefSeq Peptide - NP_958787
RefSeq Peptide - NP_958788
RefSeq Peptide - NP_958789
RefSeq Peptide - NP_958790
RefSeq Peptide - NP_001157014
RefSeq Peptide - NP_958792
RefSeq Peptide - NP_958793
RefSeq Peptide - NP_958794
RefSeq Peptide - NP_958795
RefSeq Peptide - NP_958796
swissprot - E9PW24
swissprot - Q9QXS1
swissprot - E9Q9J6
swissprot - E9Q3W4
swissprot - A0A0B4J1M3
swissprot - A0A0R4J223
swissprot - A0A0R4J221
swissprot - A0A0R4J218
swissprot - A0A0B4J1M7
Ensembl - ENSMUSG00000022565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plecaENSDARG00000062590Danio rerio
 plecbENSDARG00000021987Danio rerio
 PLECENSG00000178209Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Macf1 / microtubule-actin crosslinking factor 1 / Q9UPN3*ENSMUSG0000002864925
Dst / Q91ZU6 / Dystonin / Q03001*ENSMUSG0000002613124
Dsp / E9Q557 / Desmoplakin / P15924*ENSMUSG0000005488920
Eppk1 / epiplakin 1ENSMUSG0000011538810
Evpl / Q9D952 / Envoplakin / Q92817*ENSMUSG0000003428210
Ppl / periplakin / O60437*ENSMUSG000000394578


Protein motifs (from Interpro)
Interpro ID Name
 IPR001101  Plectin repeat
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002017  Spectrin repeat
 IPR005326  Plectin/S10, N-terminal
 IPR018159  Spectrin/alpha-actinin
 IPR030269  Plectin
 IPR035915  Plakin repeat superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031581 hemidesmosome assembly ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005925 focal adhesion ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030056 hemidesmosome ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0043292 contractile fiber IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0008307 structural constituent of muscle ISO
 molecular_functionGO:0030506 ankyrin binding ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Assembly of collagen fibrils and other multimeric structures
Caspase-mediated cleavage of cytoskeletal proteins
Type I hemidesmosome assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Efemp1tm1Eap/Efemp1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf4tm1Aki/Atf4tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(KRT5-cre)1Tak/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Plectm2Gwi/Plectm4Gwi,Tg(Krt1-5-cre/ERT)1Ipc/?
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(KRT5-cre)1Tak/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(KRT5-cre)1Tak/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Plectm7.1Gwi/Plectm7.1Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plectm7.1Gwi/Plec+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001232 absent basal layer "missing the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Plectm2Gwi/Plectm4Gwi,Tg(Krt1-5-cre/ERT)1Ipc/?
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Plectm2Gwi/Plectm4Gwi,Tg(Krt1-5-cre/ERT)1Ipc/?
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(KRT5-cre)1Tak/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atf4tm1Aki/Atf4tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Plectm7.1Gwi/Plectm7.1Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plectm7.1Gwi/Plec+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Plectm2Gwi/Plectm4Gwi,Tg(Krt1-5-cre/ERT)1Ipc/?
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(KRT5-cre)1Tak/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003081 abnormal soleus morphology "anomaly in the the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

Allelic Composition: Plectm5Gwi/Plectm5Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Plectm7.1Gwi/Plec+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

Allelic Composition: Plectm4Gwi/Plectm4.1Gwi,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

Allelic Composition: Plectm5Gwi/Plectm5Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm5Gwi/Plectm5Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

Allelic Composition: Plectm5Gwi/Plectm5Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

Allelic Composition: Plectm5Gwi/Plectm5Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009473 abnormal skin exfoliation "anomaly in the process of detachment and shedding of superficial cells of a skin epithelium" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm7.1Gwi/Plectm7.1Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plectm7.1Gwi/Plec+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009827 skin detachment "loss of sections of skin either spontaneously or after gentle handling" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Plectm5Gwi/Plectm5Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(KRT5-cre)1Tak/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011160 dermal-epidermal separation "the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis" [MGI:csmith]
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Allelic Composition: Plectm7.1Gwi/Plectm7.1Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plectm7.1Gwi/Plec+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Plectm4Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

Allelic Composition: Plectm1Gwi/Plectm4Gwi,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB

 MP:0020416 decreased fibroblast chemotaxis "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna, PMID:20231695]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / reaction / complex
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / complex / reaction
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / complex / reaction
 ENSMUSG00000020758 Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*  / reaction / complex
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / reaction / complex
 ENSMUSG00000025064 Q07563 / Col17a1 / Collagen alpha-1(XVII) chain 120 kDa linear IgA disease antigen homolog / Q9UMD9* / collagen type XVII alpha 1 chain*  / reaction / complex
 ENSMUSG00000025510 Cd151 / O35566 / CD151 antigen / P48509* / CD151 molecule (Raph blood group)*  / reaction / complex
 ENSMUSG00000026131 Dst / Q91ZU6 / Dystonin / Q03001*  / complex






 

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