ENSMUSG00000027111


Mus musculus

Features
Gene ID: ENSMUSG00000027111
  
Biological name :Itga6
  
Synonyms : Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / Itga6 / Q61739
  
Possible biological names infered from orthology : integrin subunit alpha 6 / P23229
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 71745616
Gene end: 71858416
  
Corresponding Affymetrix probe sets: 10472820 (MoGene1.0st)   1422444_at (Mouse Genome 430 2.0 Array)   1422445_at (Mouse Genome 430 2.0 Array)   1431135_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028522
Ensembl peptide - ENSMUSP00000107729
Ensembl peptide - ENSMUSP00000118086
NCBI entrez gene - 16403     See in Manteia.
MGI - MGI:96605
RefSeq - XM_017315707
RefSeq - NM_001277970
RefSeq - NM_008397
RefSeq - XM_011239308
RefSeq - XM_011239309
RefSeq Peptide - NP_001264899
RefSeq Peptide - NP_032423
swissprot - Q61739
swissprot - Q8CC06
swissprot - F6VSK8
Ensembl - ENSMUSG00000027111
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU469503.1ENSDARG00000099348Danio rerio
 itga6aENSDARG00000042282Danio rerio
 itga6bENSDARG00000069946Danio rerio
 itga6lENSDARG00000056018Danio rerio
 ITGA6ENSGALG00000034007Gallus gallus
 ITGA6ENSG00000091409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534848
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150737
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676827
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055527
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708727
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911525
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700924
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466424
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021022
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224321
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228420
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078920
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553320
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594719
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078619
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859618
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083018
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010668 ectodermal cell differentiation IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0022409 positive regulation of cell-cell adhesion IDA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 biological_processGO:0033627 cell adhesion mediated by integrin IDA
 biological_processGO:0035878 nail development IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0097186 amelogenesis IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030056 hemidesmosome IDA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0034676 integrin alpha6-beta4 complex IEA
 cellular_componentGO:0045178 basal part of cell IDA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0038132 neuregulin binding IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Assembly of collagen fibrils and other multimeric structures
Basigin interactions
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
Type I hemidesmosome assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000452 abnormal mouth morphology "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgaltm1Hlz/Itgaltm1Hlz
Genetic Background: involves: 129P2/OlaHsd

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

Allelic Composition: Itga6tm2Egl/Itga6tm2Egl,Itga7tm1Umr/Itga7tm1Umr,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgaltm1Hlz/Itgaltm1Hlz
Genetic Background: involves: 129P2/OlaHsd

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Ikzf1tm2Kge/Ikzf1tm2.1Smale
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Itgaltm1Hlz/Itgaltm1Hlz
Genetic Background: involves: 129P2/OlaHsd

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Xisttm2Nbd/Xist+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xisttm2Nbd/Xist+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

Allelic Composition: Itga6tm2Egl/Itga6tm2Egl,Itga7tm1Umr/Itga7tm1Umr,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Itga6tm1Egl/Itga6tm1Egl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003591 urethra atresia "closure, or failure to develop a connection in the canal that leads from the bladder and discharges urine externally" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xisttm2Nbd/Xist+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

Allelic Composition: Itga6tm2Egl/Itga6tm2Egl,Itga7tm1Umr/Itga7tm1Umr,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itga6tm1Egl/Itga6tm1Egl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Itga6tm1Egl/Itga6tm1Egl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)

 MP:0008442 disorganized cortical plate "derangement of the patterned arrangement of the cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itga6tm1Egl/Itga6tm1Egl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)

 MP:0008509 disorganized retinal ganglion layer "derangement of the pattern of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009252 absent urinary bladder "absence of the inflatable musculomembranous bag for holding urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009569 abnormal left lung morphology "any structural anomaly of the organ of respiration located on the left side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009570 abnormal right lung morphology "any structural anomaly of the organ of respiration located on the right side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

Allelic Composition: Itga6tm2Egl/Itga6tm2Egl,Itga7tm1Umr/Itga7tm1Umr,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

 MP:0010116 abnormal primitive urogenital sinus morphology "any structural anomaly of the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011011 impaired lung lobe morphogenesis "failure to form any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011032 impaired branching involved in terminal bronchiole morphogenesis 
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Itga6tm1Egl/Itga6tm1Egl
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)

Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011730 increased myelin sheath thickness "increase in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
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Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
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Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

 MP:0011904 abnormal Schwann cell physiology "any functional anomaly of the cells which form the insulating myelin sheaths of peripheral axons" [MESH:A08.637.800]
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Allelic Composition: Itga6tm2.1Egl/Itga6tm2.1Egl
Genetic Background: involves: C57BL/6

Allelic Composition: Itga6tm2Egl/Itga6tm2Egl,Itga7tm1Umr/Itga7tm1Umr,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

 MP:0020452 abnormal axon radial sorting "any anomaly in the process by which immature Schwann cells surround axons of mixed caliber and send cytoplasmic processes that resemble lamellipodia between axons, to progressively choose and segregate the larger axons at the periphery of the bundle" [MGI:smb, PMID:25686621]
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Allelic Composition: Itga6tm2Egl/Itga6tm2Egl,Itga7tm1Umr/Itga7tm1Umr,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / complex / reaction
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / complex / reaction
 ENSMUSG00000015647 Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*  / complex / reaction
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / reaction / complex
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / reaction / complex
 ENSMUSG00000022565 Plec / Q9QXS1 / plectin / Q15149*  / reaction / complex
 ENSMUSG00000020758 Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*  / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / reaction / complex
 ENSMUSG00000025064 Q07563 / Col17a1 / Collagen alpha-1(XVII) chain 120 kDa linear IgA disease antigen homolog / Q9UMD9* / collagen type XVII alpha 1 chain*  / reaction / complex
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / complex / reaction
 ENSMUSG00000025510 Cd151 / O35566 / CD151 antigen / P48509* / CD151 molecule (Raph blood group)*  / complex / reaction
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / reaction / complex
 ENSMUSG00000026131 Dst / Q91ZU6 / Dystonin / Q03001*  / reaction / complex






 

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