ENSMUSG00000002900


Mus musculus

Features
Gene ID: ENSMUSG00000002900
  
Biological name :Lamb1
  
Synonyms : Lamb1 / Laminin subunit beta-1 / P02469
  
Possible biological names infered from orthology : P07942
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A2
Gene start: 31265234
Gene end: 31329644
  
Corresponding Affymetrix probe sets: 10395163 (MoGene1.0st)   1424113_at (Mouse Genome 430 2.0 Array)   1424114_s_at (Mouse Genome 430 2.0 Array)   1446180_at (Mouse Genome 430 2.0 Array)   1451241_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132001
Ensembl peptide - ENSMUSP00000132778
Ensembl peptide - ENSMUSP00000002979
NCBI entrez gene - 16777     See in Manteia.
MGI - MGI:96743
RefSeq - XM_006514992
RefSeq - XM_006514993
RefSeq - NM_008482
RefSeq Peptide - NP_032508
swissprot - P02469
swissprot - E9QN70
swissprot - E9Q339
Ensembl - ENSMUSG00000002900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamb1aENSDARG00000101209Danio rerio
 lamb1bENSDARG00000045524Danio rerio
 LAMB1ENSGALG00000007905Gallus gallus
 LAMB1ENSG00000091136Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291150
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564724
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442122
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG0000002663921
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989921
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279620
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG0000002647817
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG0000002684016
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG0000002001912
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG0000002647911
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG0000001984610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR013015  Laminin IV type B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0007611 learning or memory NAS
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0042476 odontogenesis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0005606 laminin-1 complex IEA
 cellular_componentGO:0005607 laminin-2 complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043256 laminin complex IDA
 cellular_componentGO:0043257 laminin-8 complex IEA
 cellular_componentGO:0043259 laminin-10 complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005178 integrin binding IMP
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0043208 glycosphingolipid binding IDA


Pathways (from Reactome)
Pathway description
Laminin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0002980 abnormal postural reflex "failure to respond with the normal extension of legs to maintain balance when the cage is tilted" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88306]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0011187 abnormal parietal endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]
Show

Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0012057 abnormal mural trophectoderm morphology "any structural anomaly of the trophectoderm portion distal to the ICM that overlays the blastocyst cavity and gives rise to polyploid trophoblast giant cells" [MGI:anna]
Show

Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0013179 wavy tail "undulations or a sinusoidal shape of the tail" [MGI:anna]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032796 Lama1 / laminin subunit alpha 1 / P25391*  / complex
 ENSMUSG00000015647 Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*  / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / reaction / complex
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / complex / reaction
 ENSMUSG00000020758 Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*  / reaction / complex
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / reaction / complex
 ENSMUSG00000019846 Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*  / complex
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / complex
 ENSMUSG00000026840 Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*  / complex
 ENSMUSG00000031503 Col4a2 / P08122 / Collagen alpha-2(IV) chain Canstatin / P08572* / collagen type IV alpha 2 chain*  / reaction / complex
 ENSMUSG00000031502 Col4a1 / P02463 / Collagen alpha-1(IV) chain Arresten / P02462* / collagen type IV alpha 1 chain*  / reaction / complex
 ENSMUSG00000019899 Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*  / complex
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / complex
 ENSMUSG00000001435 P39061 / Col18a1 / Collagen alpha-1(XVIII) chain Endostatin Non-collagenous domain 1 / P39060* / collagen type XVIII alpha 1 chain*  / complex / reaction






 

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