ENSMUSG00000001507


Mus musculus

Features
Gene ID: ENSMUSG00000001507
  
Biological name :Itga3
  
Synonyms : Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / Itga3 / Q62470
  
Possible biological names infered from orthology : integrin subunit alpha 3 / P26006
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 95044474
Gene end: 95076801
  
Corresponding Affymetrix probe sets: 10390117 (MoGene1.0st)   1421997_s_at (Mouse Genome 430 2.0 Array)   1455158_at (Mouse Genome 430 2.0 Array)   1460305_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001548
Ensembl peptide - ENSMUSP00000103368
Ensembl peptide - ENSMUSP00000113556
Ensembl peptide - ENSMUSP00000115970
NCBI entrez gene - 16400     See in Manteia.
MGI - MGI:96602
RefSeq - XM_006532311
RefSeq - NM_001306071
RefSeq - NM_001306162
RefSeq - NM_013565
RefSeq - XM_006532310
RefSeq Peptide - NP_001293091
RefSeq Peptide - NP_038593
RefSeq Peptide - NP_001293000
swissprot - Q62470
swissprot - F6UD16
Ensembl - ENSMUSG00000001507
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga3aENSDARG00000037917Danio rerio
 itga3bENSDARG00000012824Danio rerio
 ITGA3ENSGALG00000032702Gallus gallus
 ITGA3ENSG00000005884Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534838
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711138
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466425
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708725
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676825
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911524
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055524
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700923
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021022
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224322
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228421
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553321
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036920
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594720
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859620
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083020
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078920
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030510 regulation of BMP signaling pathway IEA
 biological_processGO:0031345 negative regulation of cell projection organization IEA
 biological_processGO:0034698 response to gonadotropin IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IGI
 biological_processGO:0035640 exploration behavior IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0072006 nephron development IEA
 biological_processGO:0097062 dendritic spine maintenance IMP
 biological_processGO:0097205 renal filtration IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031527 filopodium membrane ISS
 cellular_componentGO:0034667 integrin alpha3-beta1 complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0060076 excitatory synapse IDA
 cellular_componentGO:0071438 invadopodium membrane ISO
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0097060 synaptic membrane IDA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Integrin cell surface interactions
Laminin interactions
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

Allelic Composition: Itga3tm1Jak/Itga3+,Itga5tm1Hyn/Itga5+,Itga8tm1Lfr/Itga8+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Itga3tm1Rdav/Itga3tm1Rdav,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: B6.Cg-Itga3tm1Rdav Tg(Camk2a-cre)T29-1Stl

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm

 MP:0003591 urethra atresia "closure, or failure to develop a connection in the canal that leads from the bladder and discharges urine externally" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004202 pulmonary hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004757 abnormal distal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008138 absent podocyte foot process "absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itga3tm1Rdav/Itga3tm1Rdav,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: B6.Cg-Itga3tm1Rdav Tg(Camk2a-cre)T29-1Stl

 MP:0008509 disorganized retinal ganglion layer "derangement of the pattern of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009252 absent urinary bladder "absence of the inflatable musculomembranous bag for holding urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009569 abnormal left lung morphology "any structural anomaly of the organ of respiration located on the left side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009570 abnormal right lung morphology "any structural anomaly of the organ of respiration located on the right side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/?
Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm

 MP:0010116 abnormal primitive urogenital sinus morphology "any structural anomaly of the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0010896 decreased lung compliance "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0010897 abnormal bronchiole epithelium morphology "any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011011 impaired lung lobe morphogenesis "failure to form any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011028 impaired branching involved in bronchus morphogenesis 
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011032 impaired branching involved in terminal bronchiole morphogenesis 
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dlx5tm1Jlr/Dlx5+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0011359 decreased glomerular capillary number "reduced number of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles" [MGI:csmith]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0011509 dilated glomerular capillary "stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011846 decreased kidney collecting duct number "smaller than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance" [MGI:anna]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / reaction / complex
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / reaction / complex
 ENSMUSG00000015647 Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*  / reaction / complex
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / complex / reaction
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / complex / reaction
 ENSMUSG00000040152 Thbs1 / thrombospondin 1 / P07996*  / reaction / complex
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / reaction / complex
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / reaction / complex
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex






 

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