ENSMUSG00000027087


Mus musculus

Features
Gene ID: ENSMUSG00000027087
  
Biological name :Itgav
  
Synonyms : Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / Itgav / P43406
  
Possible biological names infered from orthology : integrin subunit alpha V / P06756
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: D
Gene start: 83724397
Gene end: 83806916
  
Corresponding Affymetrix probe sets: 10473281 (MoGene1.0st)   1421198_at (Mouse Genome 430 2.0 Array)   1432296_a_at (Mouse Genome 430 2.0 Array)   1432678_at (Mouse Genome 430 2.0 Array)   1432679_at (Mouse Genome 430 2.0 Array)   1452784_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118016
Ensembl peptide - ENSMUSP00000122730
Ensembl peptide - ENSMUSP00000121295
Ensembl peptide - ENSMUSP00000028499
Ensembl peptide - ENSMUSP00000107369
NCBI entrez gene - 16410     See in Manteia.
MGI - MGI:96608
RefSeq - XM_006498807
RefSeq - NM_008402
RefSeq Peptide - NP_032428
swissprot - F6W6Q6
swissprot - A2AKI5
swissprot - B7ZCI9
swissprot - P43406
swissprot - F6RWM8
Ensembl - ENSMUSG00000027087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgavENSDARG00000006314Danio rerio
 ITGAVENSGALG00000002655Gallus gallus
 ITGAVENSG00000138448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676847
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055545
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466437
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534830
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711128
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150725
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700925
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911524
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224322
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078922
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036922
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078621
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553321
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228421
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083020
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859620
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021020
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009566 fertilization NAS
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0032369 negative regulation of lipid transport IEA
 biological_processGO:0032490 detection of molecule of bacterial origin TAS
 biological_processGO:0033627 cell adhesion mediated by integrin IDA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IMP
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035262 gonad morphogenesis NAS
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0038027 apolipoprotein A-I-mediated signaling pathway IEA
 biological_processGO:0038044 transforming growth factor-beta secretion IDA
 biological_processGO:0042110 T cell activation TAS
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043542 endothelial cell migration TAS
 biological_processGO:0045124 regulation of bone resorption TAS
 biological_processGO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048041 focal adhesion assembly NAS
 biological_processGO:0050748 negative regulation of lipoprotein metabolic process IEA
 biological_processGO:0050764 regulation of phagocytosis IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol TAS
 biological_processGO:0060707 trophoblast giant cell differentiation TAS
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071731 response to nitric oxide TAS
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:2000536 negative regulation of entry of bacterium into host cell IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0034683 integrin alphav-beta3 complex TAS
 cellular_componentGO:0034684 integrin alphav-beta5 complex IDA
 cellular_componentGO:0034685 integrin alphav-beta6 complex IDA
 cellular_componentGO:0034686 integrin alphav-beta8 complex IEA
 cellular_componentGO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex IEA
 cellular_componentGO:0035868 alphav-beta3 integrin-HMGB1 complex IEA
 molecular_functionGO:0001846 opsonin binding IDA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IEA
 molecular_functionGO:0019960 C-X3-C chemokine binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0038132 neuregulin binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity TAS
 molecular_functionGO:0050431 transforming growth factor beta binding ISS
 molecular_functionGO:0050840 extracellular matrix binding IEA
 molecular_functionGO:1990430 extracellular matrix protein binding IEA


Pathways (from Reactome)
Pathway description
Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Signal transduction by L1
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6tm1Lan/Pax6tm1Lan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6tm1Lan/Pax6tm1Lan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6tm1Lan/Pax6tm1Lan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6tm1Lan/Pax6tm1Lan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Pax6tm1Lan/Pax6tm1Lan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001711 abnormal placenta 
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6tm1Lan/Pax6tm1Lan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6tm1Lan/Pax6tm1Lan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igf1rtm2.1Arge/Igf1rtm2.1Arge
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

Allelic Composition: Itgavtm2.1Hyn/Itgavtm2.1Hyn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6tm1Lan/Pax6tm1Lan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itga5tm2Hyn/Itga5tm2Hyn,Itgavtm2Hyn/Itgavtm2Hyn,Tg(H2-K1-tsA58)11Kio/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003225 axonal dystrophy "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Itga5tm2Hyn/Itga5tm2Hyn,Itgavtm2Hyn/Itgavtm2Hyn,Tg(H2-K1-tsA58)11Kio/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0005502 abnormal urinary system physiology "functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0006052 cerebellum hemorrhage "bleeding into the cerebellum" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB * SJL

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgavtm2Hyn/Itgavtm2.1Hyn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009867 abnormal ascending aorta morphology "any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm2Hyn/Itgav+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm2Hyn/Itgav+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Itgavtm1Hyn/Itgavtm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031849 Comp / Q9R0G6 / Cartilage oligomeric matrix protein / P49747*  / complex / reaction
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / complex / reaction
 ENSMUSG00000059456 Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / complex / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000029307 Dmp1 / O55188 / Dentin matrix acidic phosphoprotein 1 / Q13316*  / reaction / complex
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000025321 Itgb8 / integrin subunit beta 8 / P26012*  / complex
 ENSMUSG00000028364 Tnc / Q80YX1 / tenascin C / P24821*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction
 ENSMUSG00000029306 Ibsp / Q61711 / Bone sialoprotein 2 / P21815* / integrin binding sialoprotein*  / reaction / complex
 ENSMUSG00000026971 Itgb6 / Q9Z0T9 / Integrin beta-6 / P18564* / integrin subunit beta 6*  / complex
 ENSMUSG00000022817 Itgb5 / integrin subunit beta 5 / P18084*  / complex
 ENSMUSG00000053268 Dspp / Q9NZW4* / dentin sialophosphoprotein*  / complex / reaction






 

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