ENSMUSG00000032243


Mus musculus

Features
Gene ID: ENSMUSG00000032243
  
Biological name :Itga11
  
Synonyms : integrin subunit alpha 11 / Itga11
  
Possible biological names infered from orthology : Q9UKX5
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 62677826
Gene end: 62783982
  
Corresponding Affymetrix probe sets: 10586079 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000034774
NCBI entrez gene - 319480     See in Manteia.
MGI - MGI:2442114
RefSeq - NM_176922
RefSeq Peptide - NP_795896
swissprot - A0A0B4J1F0
Ensembl - ENSMUSG00000032243
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga11aENSDARG00000036086Danio rerio
 itga11bENSDARG00000007950Danio rerio
 ITGA11ENSGALG00000008007Gallus gallus
 ITGA11ENSG00000137809Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021042
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228440
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553335
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036927
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078927
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859626
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078626
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083026
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594724
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911521
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700921
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150720
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534820
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708719
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055519
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711119
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676819
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006929 substrate-dependent cell migration IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0038065 collagen-activated signaling pathway IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034681 integrin alpha11-beta1 complex IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0038064 collagen receptor activity IEA
 molecular_functionGO:0098639 collagen binding involved in cell-matrix adhesion IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Itga11m1Btlr/Itga11m1Btlr
Genetic Background: C57BL/6J-Itga11m1Btlr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003053 delayed tooth eruption "postponed onset of the growth of the teeth out of the gums" [pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003668 abnormal periodontal ligament morphology "any structural anomaly in the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66512]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0004830 short incisors "reduced length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0030460 enamel pits "presence of small depressions in the dental enamel" [HP:0009722]
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Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

 MP:0030509 increased number of epithelial cell rests of Malassez "increased number of epithelial cell remnants derived from the fragmentation of Hertwig s epithelial root sheath during root development that persist in the periodontal ligament close to the cementum surface" [CL:0002166, http://dental.pitt.edu/periohistology-glossary#cellrestsofmalassez]
Show

Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex






 

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