ENSMUSG00000025809


Mus musculus

Features
Gene ID: ENSMUSG00000025809
  
Biological name :Itgb1
  
Synonyms : Integrin beta-1 / Itgb1 / P09055
  
Possible biological names infered from orthology : integrin subunit beta 1 / P05556
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E2
Gene start: 128685654
Gene end: 128733200
  
Corresponding Affymetrix probe sets: 10576661 (MoGene1.0st)   1426918_at (Mouse Genome 430 2.0 Array)   1426919_at (Mouse Genome 430 2.0 Array)   1426920_x_at (Mouse Genome 430 2.0 Array)   1427771_x_at (Mouse Genome 430 2.0 Array)   1430630_at (Mouse Genome 430 2.0 Array)   1438119_at (Mouse Genome 430 2.0 Array)   1452545_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087457
Ensembl peptide - ENSMUSP00000120026
Ensembl peptide - ENSMUSP00000119699
NCBI entrez gene - 16412     See in Manteia.
MGI - MGI:96610
RefSeq - NM_010578
RefSeq Peptide - NP_034708
swissprot - D6RJL5
swissprot - A0A0A0MQJ3
swissprot - P09055
Ensembl - ENSMUSG00000025809
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01058721.1ENSDARG00000109929Danio rerio
 itgb1aENSDARG00000071863Danio rerio
 itgb1bENSDARG00000104484Danio rerio
 ITGB1ENSGALG00000007145Gallus gallus
 ITGB1ENSG00000150093Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgb2 / P05107* / integrin subunit beta 2*ENSMUSG0000000029045
Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*ENSMUSG0000002068943
Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*ENSMUSG0000000128142
Itgb6 / Q9Z0T9 / Integrin beta-6 / P18564* / integrin subunit beta 6*ENSMUSG0000002697140
Itgb5 / integrin subunit beta 5 / P18084*ENSMUSG0000002281740
Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*ENSMUSG0000002075836
Itgb2l / Q3UV74 / Integrin beta-2-like protein / ITGB2* / P05107* / integrin subunit beta 2*ENSMUSG0000000015733
Itgb8 / integrin subunit beta 8 / P26012*ENSMUSG0000002532131
Itgbl1 / Q8VDV0 / Integrin beta-like protein 1 / O95965* / integrin subunit beta like 1*ENSMUSG0000003292515


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR013111  EGF-like domain, extracellular
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027071  Integrin beta-1 subunit
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007161 calcium-independent cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008354 germ cell migration IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010710 regulation of collagen catabolic process IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021943 formation of radial glial scaffolds IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0033631 cell-cell adhesion mediated by integrin IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IGI
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IDA
 biological_processGO:0071711 basement membrane organization IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0034665 integrin alpha1-beta1 complex IEA
 cellular_componentGO:0034666 integrin alpha2-beta1 complex IEA
 cellular_componentGO:0034667 integrin alpha3-beta1 complex IEA
 cellular_componentGO:0034677 integrin alpha7-beta1 complex IPI
 cellular_componentGO:0034680 integrin alpha10-beta1 complex IEA
 cellular_componentGO:0034681 integrin alpha11-beta1 complex IEA
 cellular_componentGO:0035748 myelin sheath abaxonal region IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0071438 invadopodium membrane ISO
 cellular_componentGO:0097060 synaptic membrane IDA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019960 C-X3-C chemokine binding IEA
 molecular_functionGO:0043236 laminin binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0098639 collagen binding involved in cell-matrix adhesion IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Signal transduction by L1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
MET activates PTK2 signaling
MET interacts with TNS proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000022 abnormal ear shape "malformation of the pattern of the external ear" [J:65038]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000023 abnormal ear distance/ position "anomaly in the space between or the placement of the outer ears " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: L1camtm1Sor/Y
Genetic Background: either: 129S7/SvEvBrd-L1camtm1Sor or (129S7/SvEvBrd * C57BL/6J)F1

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: L1camtm1Sor/Y
Genetic Background: either: 129S7/SvEvBrd-L1camtm1Sor or (129S7/SvEvBrd * C57BL/6J)F1

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gphb5tm1Lex/Gphb5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gphb5tm1Lex/Gphb5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm5.1Ref/Itgb1tm5.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Itgb1tm5.1Ref/Itgb1tm5.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm1Ref/Itgb1tm5.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000381 enlarged hair follicles "increased size of the epidermal invaginations from which the hair shaft develops" [J:30249]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm15.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm5.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
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Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0000648 absent sebaceous gland "missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0001109 absent Schwann cell precursors "missing progenitors of cells that sheath the axons of the peripheral nervous system" [J:43515]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm1Ref/Itgb1tm5.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm1Ref/Itgb1tm15.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm14.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Itgb1tm5.1Ref/Itgb1tm5.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mdm4tm3Glo/Mdm4tm3.1Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Gphb5tm1Lex/Gphb5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm13.1Ref/Itgb1tm13.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0001711 abnormal placenta 
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0001727 abnormal embryo implantation "failure or reduced ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm13.1Ref/Itgb1tm13.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm5.1Ref/Itgb1tm5.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm15.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm14.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm4tm3Glo/Mdm4tm3.1Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gphb5tm1Lex/Gphb5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Itgb1tm4Ref/Itgb1tm4Ref,Tg(Ins2-cre)1Heed/?,Tg(RIP1-Tag)2Dh/?
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * DBA/2J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd4tm2Litt/Cd4tm2Litt,Tfap4tm1.1Litt/Tfap4tm1.1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Itgb1tm7.1Ref/Itgb1tm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm8.1Ref/Itgb1tm8.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm9.1Ref/Itgb1tm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm9.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: L1camtm1Sor/Y
Genetic Background: either: 129S7/SvEvBrd-L1camtm1Sor or (129S7/SvEvBrd * C57BL/6J)F1

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: Itgb1tm13.1Ref/Itgb1tm13.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eportm1Jae/Epor+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm14.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0002926 aganglionic megacolon "extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Ins2-cre)1Heed/?,Tg(RIP1-Tag)2Dh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA * DBA/2J

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Ins2-cre)1Heed/?,Tg(RIP1-Tag)2Dh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA * DBA/2J

 MP:0003604 single kidney 
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003626 kidney medulla hypoplasia 
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: a/a,Mlphln/Mlphln,Tyrp1b/Tyrp1b
Genetic Background: C57L/J

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004039 abnormal cardiac cell glucose uptake "anomalous ability of the cells of the heart to take in glucose" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Ins2-cre)1Heed/?,Tg(RIP1-Tag)2Dh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA * DBA/2J

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm9.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004867 decreased platelet calcium level "decreased concentration in the platelet of this bivalent element" [RGD:Rat Genome Database submission]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0004963 abnormal blastocoele morphology "any structural anomaly the fluid-filled cavity of the blastocyst of the preimplantation embryo of mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eportm1Jae/Epor+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm1.1Efu/Itgb1tm1.1Efu
Genetic Background: involves: 129X1/SvJ

 MP:0004965 inner cell mass degeneration 
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Allelic Composition: Eportm1Jae/Epor+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Eportm1Jae/Epor+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005035 perianal ulceration "lesion around or near the anus" [cml:Cathy M Lutz , Mouse Genome Informatics Curator, J:71506]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb1tm1.1Efu/Itgb1tm1.1Efu
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005556 abnormal kidney clearance "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Atoh7tm1.1(Ascl1)Nlbr/Atoh7+,Tg(Atoh7-cre)360Gla/0,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

Allelic Composition: Itgb1tm15.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0005623 abnormal meninges "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005664 decreased circulating noradrenaline level "less than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Itgb1tm1Mll/Itgb1tm1Mll,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Ins2-cre)1Heed/?,Tg(RIP1-Tag)2Dh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA * DBA/2J

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0008030 abnormal Cajal-Retzius cell morphology "any abnormality of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm5.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Gphb5tm1Lex/Gphb5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gphb5tm1Lex/Gphb5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0009385 abnormal dermal pigmentation "anomaly in coloration of the dermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm5.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm5.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm15.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009964 abnormal cerebellum lobule morphology "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0010334 pleural effusion "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0010387 abnormal Bergmann glial cell morphology "any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0010684 abnormal hair follicle outer root sheath morphology "any structural anomaly of the outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [PMID:19211055]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm5.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Itgb1tm9.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm14.1Ref/Itgb1tm14.1Ref
Genetic Background: Not Specified

Allelic Composition: Itgb1tm15.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm1.1Efu/Itgb1tm1.1Efu
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Lscd
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Itgb1tm5.1Ref/Itgb1tm5.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Itgb1tm5.1Ref/Itgb1tm5.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Itgb1tm13.1Ref/Itgb1tm13.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011159 abnormal epidermal-dermal junction morphology "any structural anomaly of the multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction" [PMID:1097542]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0011160 dermal-epidermal separation "the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis" [MGI:csmith]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Lscd
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0011264 abnormal cardiac mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011282 increased podocyte apoptosis "increase in the number of podocytes undergoing programmed cell death; podocyte apoptosis is an early step in the pathophysiological progression to proteinuria and glomerulosclerosis" [MGI:anna]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011307 kidney medulla cysts "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Itgb1tm13.1Ref/Itgb1tm13.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm14.1Ref/Itgb1tm14.1Ref
Genetic Background: Not Specified

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011417 abnormal renal transport "any anomaly of the directed movement of substances through the kidney" [MGI:csmith]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011430 mesangiolysis "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011509 dilated glomerular capillary "stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna]
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Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm14.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

 MP:0012263 decreased hindbrain size "size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
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Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0012702 increased embryonic neuroepithelium thickness "increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0013001 abnormal enteric neural crest cell morphology " any structural anomaly of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; neural crest cells are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans)" [MGI:anna, PMID:17514199]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0013006 abnormal enteric neural crest cell migration "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; NCCs are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) and the colonization process is complete by E15.5 (after 7 weeks gestation in humans)" [MGI:anna, PMID:17514199]
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Allelic Composition: Myo5ad-n2J/Myo5ad-n2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0013305 isosthenuria "inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake" [MGI:Anna]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0014103 increased chondrocyte apoptosis "increased number of chondrocytes undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm2Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0020391 radial glial endfoot detachment "detachment of the radial glia cell endfoot from the pial basement membrane" [MGI:anna, PMID:17715063, PMID:23217742, PMID:24256719]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0030578 decreased keratinocyte adhesion "decreased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [MGI:anna]
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Allelic Composition: Itgb1tm9.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itgb1tm1Ref/Itgb1tm12.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Allelic Composition: Itgb1tm1Ref/Itgb1tm15.1Ref,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / reaction / complex
 ENSMUSG00000031849 Comp / Q9R0G6 / Cartilage oligomeric matrix protein / P49747*  / complex / reaction
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / complex / reaction
 ENSMUSG00000015647 Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*  / complex / reaction
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / reaction / complex
 ENSMUSG00000026768 Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*  / complex
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / reaction / complex
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / reaction / complex
 ENSMUSG00000000555 Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*  / complex
 ENSMUSG00000031990 Jam3 / Q9D8B7 / Junctional adhesion molecule C / Q9BX67* / junctional adhesion molecule 3*  / complex / reaction
 ENSMUSG00000090210 Itga10 / integrin subunit alpha 10 / O75578*  / complex
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / complex
 ENSMUSG00000028763 Hspg2 / perlecan (heparan sulfate proteoglycan 2) / P98160* / heparan sulfate proteoglycan 2*  / reaction / complex
 ENSMUSG00000030890 Ilk / O55222 / Integrin-linked protein kinase / Q13418* / integrin linked kinase*  / complex / reaction
 ENSMUSG00000028364 Tnc / Q80YX1 / tenascin C / P24821*  / complex / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction / complex
 ENSMUSG00000032243 Itga11 / integrin subunit alpha 11 / Q9UKX5*  / complex
 ENSMUSG00000039115 Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*  / complex
 ENSMUSG00000027962 Vcam1 / P29533 / vascular cell adhesion molecule 1 / P19320*  / complex / reaction
 ENSMUSG00000036446 Lum / P51885 / Lumican / P51884*  / reaction / complex
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / complex
 ENSMUSG00000030789 Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*  / complex
 ENSMUSG00000040152 Thbs1 / thrombospondin 1 / P07996*  / reaction / complex
 ENSMUSG00000030077 Chl1 / P70232 / Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein / O00533* / cell adhesion molecule L1 like*  / reaction / complex
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / reaction / complex
 ENSMUSG00000015533 Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*  / complex
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / complex / reaction
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction / complex
 ENSMUSG00000042284 Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*  / complex
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / complex / reaction
 ENSMUSG00000038264 Q9QUR8 / Sema7a / Semaphorin-7A / O75326* / semaphorin 7A (John Milton Hagen blood group)*  / reaction / complex
 ENSMUSG00000029304 Spp1 / P10923 / secreted phosphoprotein 1 / P10451*  / complex / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / complex
 ENSMUSG00000017607 Tns4 / Q8BZ33 / Tensin-4 / Q8IZW8*  / complex
 ENSMUSG00000053062 Jam2 / Q9JI59 / Junctional adhesion molecule B / P57087* / junctional adhesion molecule 2*  / complex / reaction
 ENSMUSG00000027009 Itga4 / integrin subunit alpha 4 / P13612*  / complex
 ENSMUSG00000025348 Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*  / complex
 ENSMUSG00000053268 Dspp / Q9NZW4* / dentin sialophosphoprotein*  / complex / reaction






 

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