ENSMUSG00000000290


Mus musculus

Features
Gene ID: ENSMUSG00000000290
  
Biological name :Itgb2
  
Synonyms : Itgb2
  
Possible biological names infered from orthology : integrin subunit beta 2 / P05107
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 77530252
Gene end: 77565708
  
Corresponding Affymetrix probe sets: 10364262 (MoGene1.0st)   1450678_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000299
Ensembl peptide - ENSMUSP00000119657
Ensembl peptide - ENSMUSP00000137734
Ensembl peptide - ENSMUSP00000137865
Ensembl peptide - ENSMUSP00000118191
NCBI entrez gene - 16414     See in Manteia.
MGI - MGI:96611
RefSeq - XM_017313814
RefSeq - NM_008404
RefSeq - XM_006513271
RefSeq - XM_006513272
RefSeq Peptide - NP_032430
swissprot - D3YYP8
swissprot - Q542I8
swissprot - M0QWA7
swissprot - M0QWJ6
swissprot - D3Z1S4
Ensembl - ENSMUSG00000000290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb2ENSDARG00000016939Danio rerio
 ITGB2ENSGALG00000007511Gallus gallus
 ITGB2ENSG00000160255Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgb2l / Q3UV74 / Integrin beta-2-like protein / ITGB2* / P05107* / integrin subunit beta 2*ENSMUSG0000000015756
Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*ENSMUSG0000002580947
Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*ENSMUSG0000000128146
Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*ENSMUSG0000002068938
Itgb6 / Q9Z0T9 / Integrin beta-6 / P18564* / integrin subunit beta 6*ENSMUSG0000002697138
Itgb5 / integrin subunit beta 5 / P18084*ENSMUSG0000002281737
Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*ENSMUSG0000002075833
Itgb8 / integrin subunit beta 8 / P26012*ENSMUSG0000002532131
Itgbl1 / Q8VDV0 / Integrin beta-like protein 1 / O95965* / integrin subunit beta like 1*ENSMUSG0000003292517


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015439  Integrin beta-2 subunit
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0030101 natural killer cell activation IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045123 cellular extravasation IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igkc+,Igk-Eiktm1(Igh)Xu/Igk-Eik+
Genetic Background: Not Specified

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igkc+,Igk-Eiktm1(Igh)Xu/Igk-Eik+
Genetic Background: Not Specified

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igkc+,Igk-Eiktm1(Igh)Xu/Igk-Eik+
Genetic Background: Not Specified

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: PL.129S7-Itgb2tm1Bay Itgb2tm2Bay

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: PL.129S7-Itgb2tm1Bay Itgb2tm2Bay

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/?,Psrs1PL/J/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/?,Psrs2PL/J/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/?,Psrs3PL/J/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/?,Psrs4PL/J/?
Genetic Background: involves: C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/?,Psrs5PL/J/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/?,Psrs4PL/J/Psrs4PL/J,Psrs6PL/J/Psrs6PL/J
Genetic Background: involves: C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/?,Psrs7PL/J/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit126-D10Mit38) Itgb2tm1Bay

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: PL.129S7-Itgb2tm1Bay Itgb2tm2Bay

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: PL.129S7-Itgb2tm1Bay Itgb2tm2Bay

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il15m1Hwata/Il15m1Hwata
Genetic Background: Not Specified

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Nphp3pcy/Nphp3pcy
Genetic Background: involves: KK

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igkc+,Igk-Eiktm1(Igh)Xu/Igk-Eik+
Genetic Background: Not Specified

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Mrap2tm1.1Maj/Mrap2tm1.1Maj
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002606 increased basophil count "higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: PL.129S7-Itgb2tm1Bay Itgb2tm2Bay

 MP:0003434 resistance to induced choroidal neovascularization "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit126-D10Mit38) Itgb2tm1Bay

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0003813 abnormal dermal papilla "abnormalities in this specialized group of mesenchymal cells necessary for initiation of follicle development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1.1Arte/Itgb2tm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008623 increased circulating interleukin-3 level "increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: PL.129S7-Itgb2tm1Bay Itgb2tm2Bay

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9tm1Mrc,Hoxc9tm1Mrc/Hoxc9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Itgb2tm2Bay/Itgb2tm2Bay
Genetic Background: B6.129S7-Itgb2tm2Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr