ENSMUSG00000026971


Mus musculus

Features
Gene ID: ENSMUSG00000026971
  
Biological name :Itgb6
  
Synonyms : Integrin beta-6 / Itgb6 / Q9Z0T9
  
Possible biological names infered from orthology : integrin subunit beta 6 / P18564
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.2
Gene start: 60598292
Gene end: 60722643
  
Corresponding Affymetrix probe sets: 10483000 (MoGene1.0st)   1422983_at (Mouse Genome 430 2.0 Array)   1432281_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117815
Ensembl peptide - ENSMUSP00000028348
Ensembl peptide - ENSMUSP00000054944
Ensembl peptide - ENSMUSP00000108136
NCBI entrez gene - 16420     See in Manteia.
MGI - MGI:96615
RefSeq - XM_006498811
RefSeq - NM_001159564
RefSeq - NM_021359
RefSeq - XM_006498808
RefSeq - XM_006498809
RefSeq - XM_006498810
RefSeq Peptide - NP_001153036
RefSeq Peptide - NP_067334
swissprot - B1AYG7
swissprot - Q9Z0T9
swissprot - B1AYG6
Ensembl - ENSMUSG00000026971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb6ENSDARG00000002494Danio rerio
 ITGB6ENSGALG00000011141Gallus gallus
 ITGB6ENSG00000115221Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*ENSMUSG0000002068949
Itgb5 / integrin subunit beta 5 / P18084*ENSMUSG0000002281748
Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*ENSMUSG0000002580941
Itgb2 / P05107* / integrin subunit beta 2*ENSMUSG0000000029037
Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*ENSMUSG0000000128137
Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*ENSMUSG0000002075834
Itgb8 / integrin subunit beta 8 / P26012*ENSMUSG0000002532133
Itgb2l / Q3UV74 / Integrin beta-2-like protein / ITGB2* / P05107* / integrin subunit beta 2*ENSMUSG0000000015730
Itgbl1 / Q8VDV0 / Integrin beta-like protein 1 / O95965* / integrin subunit beta like 1*ENSMUSG0000003292516


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015436  Integrin beta-6 subunit
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IDA
 biological_processGO:0038044 transforming growth factor-beta secretion IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0034685 integrin alphav-beta6 complex IDA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0005178 integrin binding IPI


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Molecules associated with elastic fibres
Integrin cell surface interactions
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
Show

Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Mmp12tm1Sds/Mmp12tm1Sds
Genetic Background: involves: 129/Sv * 129T2/SvEms

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Mmp12tm1Sds/Mmp12tm1Sds
Genetic Background: involves: 129/Sv * 129T2/SvEms

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008118 absent Langerhans cell "absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / complex / reaction
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr