ENSMUSG00000020758


Mus musculus

Features
Gene ID: ENSMUSG00000020758
  
Biological name :Itgb4
  
Synonyms : A2A863 / Integrin beta-4 / Itgb4
  
Possible biological names infered from orthology : integrin subunit beta 4 / P16144
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 115974709
Gene end: 116008412
  
Corresponding Affymetrix probe sets: 10382713 (MoGene1.0st)   1427387_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102069
Ensembl peptide - ENSMUSP00000102068
Ensembl peptide - ENSMUSP00000127604
Ensembl peptide - ENSMUSP00000021107
Ensembl peptide - ENSMUSP00000070811
Ensembl peptide - ENSMUSP00000102066
NCBI entrez gene - 192897     See in Manteia.
MGI - MGI:96613
RefSeq - XM_017314351
RefSeq - XM_006532573
RefSeq - XM_006532574
RefSeq - XM_017314349
RefSeq - XM_017314350
RefSeq - NM_001005608
RefSeq - NM_133663
RefSeq - XM_006532572
RefSeq Peptide - NP_598424
RefSeq Peptide - NP_001005608
swissprot - A2A864
swissprot - A2A863
Ensembl - ENSMUSG00000020758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb4ENSDARG00000028507Danio rerio
 ITGB4ENSGALG00000002389Gallus gallus
 ITGB4ENSG00000132470Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*ENSMUSG0000002580916
Itgb6 / Q9Z0T9 / Integrin beta-6 / P18564* / integrin subunit beta 6*ENSMUSG0000002697115
Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*ENSMUSG0000002068915
Itgb5 / integrin subunit beta 5 / P18084*ENSMUSG0000002281714
Itgb2 / P05107* / integrin subunit beta 2*ENSMUSG0000000029014
Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*ENSMUSG0000000128114
Itgb8 / integrin subunit beta 8 / P26012*ENSMUSG0000002532112
Itgb2l / Q3UV74 / Integrin beta-2-like protein / ITGB2* / P05107* / integrin subunit beta 2*ENSMUSG0000000015711
Itgbl1 / Q8VDV0 / Integrin beta-like protein 1 / O95965* / integrin subunit beta like 1*ENSMUSG000000329257


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR003644  Na-Ca exchanger/integrin-beta4
 IPR003961  Fibronectin type III
 IPR012013  Integrin beta-4 subunit
 IPR012896  Integrin beta subunit, tail
 IPR013032  EGF-like, conserved site
 IPR013783  Immunoglobulin-like fold
 IPR015812  Integrin beta subunit
 IPR033760  Integrin beta N-terminal
 IPR036116  Fibronectin type III superfamily
 IPR036349  Integrin beta tail domain superfamily
 IPR036364  SEA domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007160 cell-matrix adhesion ISO
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0009611 response to wounding ISO
 biological_processGO:0031581 hemidesmosome assembly ISO
 biological_processGO:0035878 nail development ISO
 biological_processGO:0043588 skin development ISO
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0048565 digestive tract development ISO
 biological_processGO:0048870 cell motility ISO
 biological_processGO:0061450 trophoblast cell migration IMP
 biological_processGO:0072001 renal system development ISO
 biological_processGO:0097186 amelogenesis ISO
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008305 integrin complex IDA
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030056 hemidesmosome ISO
 cellular_componentGO:0031252 cell leading edge ISO
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding ISO
 molecular_functionGO:0038132 neuregulin binding ISO


Pathways (from Reactome)
Pathway description
Assembly of collagen fibrils and other multimeric structures
Laminin interactions
Syndecan interactions
Type I hemidesmosome assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
Show

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb4tm1Mfel/Itgb4tm1.1Mfel,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Itgb4tm1.1Mfel/Itgb4tm1.1Mfel
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
Show

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0001849 ear inflammation "local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb4tm1.1Mfel/Itgb4tm1.1Mfel
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Itgb4tm1Mfel/Itgb4tm1.1Mfel,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Itgb4tm1Mfel/Itgb4tm1Mfel,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb4tm1Mfel/Itgb4tm1.1Mfel,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb4tm1Mfel/Itgb4tm1.1Mfel,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb4tm1Mfel/Itgb4tm1.1Mfel,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Itgb4tm1Mfel/Itgb4tm1Mfel,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011160 dermal-epidermal separation "the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis" [MGI:csmith]
Show

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Itgb4tm1Efu/Itgb4tm1Efu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itgb4tm1Son/Itgb4tm1Son
Genetic Background: 129P2/OlaHsd-Itgb4tm1Son

 MP:0030578 decreased keratinocyte adhesion "decreased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [MGI:anna]
Show

Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / reaction / complex
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / complex / reaction
 ENSMUSG00000015647 Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*  / reaction / complex
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / reaction / complex
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / reaction / complex
 ENSMUSG00000022565 Plec / Q9QXS1 / plectin / Q15149*  / complex / reaction
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / reaction / complex
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / complex
 ENSMUSG00000025064 Q07563 / Col17a1 / Collagen alpha-1(XVII) chain 120 kDa linear IgA disease antigen homolog / Q9UMD9* / collagen type XVII alpha 1 chain*  / reaction / complex
 ENSMUSG00000025510 Cd151 / O35566 / CD151 antigen / P48509* / CD151 molecule (Raph blood group)*  / complex / reaction
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / reaction / complex
 ENSMUSG00000026131 Dst / Q91ZU6 / Dystonin / Q03001*  / reaction / complex






 

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