ENSMUSG00000024421


Mus musculus

Features
Gene ID: ENSMUSG00000024421
  
Biological name :Lama3
  
Synonyms : Lama3 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q61789
  
Possible biological names infered from orthology : laminin subunit alpha 3 / Q16787
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 12333819
Gene end: 12583013
  
Corresponding Affymetrix probe sets: 10453939 (MoGene1.0st)   1427512_a_at (Mouse Genome 430 2.0 Array)   1444860_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089703
Ensembl peptide - ENSMUSP00000140104
NCBI entrez gene - 16774     See in Manteia.
MGI - MGI:99909
RefSeq - XM_017317841
RefSeq - NM_001347461
RefSeq - NM_010680
RefSeq - XM_006525687
RefSeq - XM_006525689
RefSeq - XM_006525690
RefSeq - XM_006525685
RefSeq - XM_006525686
RefSeq Peptide - NP_034810
RefSeq Peptide - NP_001334390
swissprot - Q61789
Ensembl - ENSMUSG00000024421
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lama3ENSDARG00000071462Danio rerio
 si:ch211-241e1.3ENSDARG00000022615Danio rerio
 ENSGALG00000043390Gallus gallus
 ENSGALG00000015056Gallus gallus
 LAMA3ENSG00000053747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564742
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989925
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279624
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG0000001984615
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291112
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290012
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG0000002647811
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG0000002684011
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG000000264798
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG000000266397
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG000000200195


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR009254  Laminin alpha, domain I
 IPR010307  Laminin domain II
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0045995 regulation of embryonic development IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005610 laminin-5 complex IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Assembly of collagen fibrils and other multimeric structures
Anchoring fibril formation
Laminin interactions
Type I hemidesmosome assembly
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0001235 disorganized suprabasal layer "anomalous organization of the suprabasal layer of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0010936 decreased airway resistance "reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0010950 abnormal lung hysteresivity "anomaly in the lung tissue property defined as the ratio of dissipated energy to stored energy over a respiratory cycle; it can be measured as the area enclosed by a pressure-volume loop of the lung, and is dependent on composition and microstructure of the tissue components such as the elastic connective tissue" [PMID:2606848]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Arnttm1Bra/Arnttm1Bra
Genetic Background: B6.129-Arnttm1Bra

 MP:0014226 abnormal alveolar macrophage physiology 
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0014228 increased alveolar macrophage number 
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0020253 increased collagen level "increased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

 MP:0020344 abnormal susceptibility to injury induced morbidity/mortality "differences from the expected moribund state caused by trauma, especially that by physical means" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: B6.Cg-Foxp3sf/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / complex
 ENSMUSG00000016942 Q9DBI0 / Tmprss6 / Mus musculus transmembrane serine protease 6 (Tmprss6), transcript variant 2, mRNA. / Q8IU80* / transmembrane serine protease 6*  / reaction
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / complex
 ENSMUSG00000025064 Q07563 / Col17a1 / Collagen alpha-1(XVII) chain 120 kDa linear IgA disease antigen homolog / Q9UMD9* / collagen type XVII alpha 1 chain*  / reaction / complex
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / complex
 ENSMUSG00000022565 Plec / Q9QXS1 / plectin / Q15149*  / reaction / complex
 ENSMUSG00000020758 Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*  / complex / reaction
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / complex / reaction
 ENSMUSG00000025510 Cd151 / O35566 / CD151 antigen / P48509* / CD151 molecule (Raph blood group)*  / complex / reaction
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / complex
 ENSMUSG00000026131 Dst / Q91ZU6 / Dystonin / Q03001*  / reaction / complex
 ENSMUSG00000000957 Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*  / reaction
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000015533 Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*  / complex / reaction
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / complex






 

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