ENSMUSG00000019899


Mus musculus

Features
Gene ID: ENSMUSG00000019899
  
Biological name :Lama2
  
Synonyms : Lama2 / Laminin subunit alpha-2 / Q60675
  
Possible biological names infered from orthology : P24043
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A4
Gene start: 26980036
Gene end: 27619758
  
Corresponding Affymetrix probe sets: 10368409 (MoGene1.0st)   1426285_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151741
Ensembl peptide - ENSMUSP00000090304
Ensembl peptide - ENSMUSP00000140716
NCBI entrez gene - 16773     See in Manteia.
MGI - MGI:99912
RefSeq - XM_017313815
RefSeq - NM_008481
RefSeq - XM_006512566
RefSeq - XM_011243134
RefSeq - XM_011243135
RefSeq Peptide - NP_032507
swissprot - A0A1W2P7N3
swissprot - A0A087WRP2
swissprot - Q60675
Ensembl - ENSMUSG00000019899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01065423.1ENSDARG00000112019Danio rerio
 lama2ENSDARG00000099390Danio rerio
 LAMA2ENSGALG00000042388Gallus gallus
 LAMA2ENSG00000196569Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279645
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564728
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442126
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG0000001984613
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291112
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG0000002684012
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290012
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG0000002647812
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG000000264798
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG000000266397
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG000000200195


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR009254  Laminin alpha, domain I
 IPR010307  Laminin domain II
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007411 axon guidance IGI
 biological_processGO:0014037 Schwann cell differentiation IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0032224 positive regulation of synaptic transmission, cholinergic IMP
 biological_processGO:0045995 regulation of embryonic development IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane ISO
 cellular_componentGO:0005605 basal lamina IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Laminin interactions
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000032 cochlear degeneration "a retrogressive impairment of function or destruction of the part of the inner ear forms the anterior part of the labyrinth, is conical, and is concerned with hearing" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

Allelic Composition: Lama2dy-6J/Lama2dy-6J
Genetic Background: involves: C57BL/6JEi * DBA/2J

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0000441 wide skull 
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Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

Allelic Composition: Lama2dy-6J/Lama2dy-6J
Genetic Background: involves: C57BL/6JEi * DBA/2J

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: involves: WK/ReJ

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

Allelic Composition: Lama2dy-6J/Lama2dy-6J
Genetic Background: involves: C57BL/6JEi * DBA/2J

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: involves: WK/ReJ

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

Allelic Composition: Lama2dy-6J/Lama2dy-6J
Genetic Background: involves: C57BL/6JEi * DBA/2J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: involves: WK/ReJ

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng,Tg(Myod1-BCL2)1Jbm/?
Genetic Background: B6.Cg-Lama2tm1Eeng Tg(Myod1-BCL2)1Jbm

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng,Tg(Myod1-BCL2)1Jbm/?
Genetic Background: B6.Cg-Lama2tm1Eeng Tg(Myod1-BCL2)1Jbm

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itih4tm1Mish/Itih4tm1Mish,Sptbn1tm1Mish/Sptbn1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0002880 opisthotonus "a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: involves: WK/ReJ

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0003851 skeletal muscle interstitial fibrosis "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: involves: 129P1/ReJ

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

 MP:0004262 abnormal physical strength "altered ability of an organism to exert force on physical objects or of the body to support its load" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0004273 abnormal basal lamina morphology "anomaly in the structure of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry,Tg(ACTB-Lama5)1Jhm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0004289 abnormal bony labyrinth "any structural abnormality in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0004300 abnormal supporting cell morphology "any structural abnormality in the highly differentiated epithelial cells with distinctive morphological features surrounding the hair cells in the organ of Corti; inner hair cells (IHCs) are normally surrounded by (inner and outer) phalangeal cells while OHCs are in contact with Deiters and pillar cells; Hensen cells are positioned further laterally in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0004325 absent vestibular hair cells "absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0004363 stria vascularis degeneration "degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0004818 increased skeletal muscle mass "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0005124 increased circulating prolactin level "greater than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009420 skeletal muscle endomysial fibrosis "replacement of the layer of connective tissue that ensheaths a muscle fiber by fibrous tissue resulting in separation of individual fibers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Lama2dy/Lama2dy
Genetic Background: B6.129P1-Lama2dy/J

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0013237 abnormal skeletal muscle regeneration "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith]
Show

Allelic Composition: Lama2dy-7J/Lama2dy-7J
Genetic Background: C57BL/6J-Lama2dy-7J/J

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0020452 abnormal axon radial sorting "any anomaly in the process by which immature Schwann cells surround axons of mixed caliber and send cytoplasmic processes that resemble lamellipodia between axons, to progressively choose and segregate the larger axons at the periphery of the bundle" [MGI:smb, PMID:25686621]
Show

Allelic Composition: Lama2dy-2J/Lama2dy-2J
Genetic Background: B6.WK-Lama2dy-2J/J

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / complex
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / complex
 ENSMUSG00000026840 Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*  / complex
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / complex






 

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