ENSMUSG00000026840


Mus musculus

Features
Gene ID: ENSMUSG00000026840
  
Biological name :Lamc3
  
Synonyms : Lamc3 / Laminin subunit gamma-3 / Q9R0B6
  
Possible biological names infered from orthology : Q9Y6N6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 31887291
Gene end: 31946539
  
Corresponding Affymetrix probe sets: 10471216 (MoGene1.0st)   1425594_at (Mouse Genome 430 2.0 Array)   1451758_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118745
Ensembl peptide - ENSMUSP00000028187
NCBI entrez gene - 23928     See in Manteia.
MGI - MGI:1344394
RefSeq - NM_011836
RefSeq Peptide - NP_035966
swissprot - A2ATM9
swissprot - Q9R0B6
Ensembl - ENSMUSG00000026840
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamc3ENSDARG00000093572Danio rerio
 LAMC3ENSG00000050555Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG0000002647843
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564729
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG0000002647923
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989923
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442123
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279622
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290019
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291119
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG0000002663913
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG000000200199
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG000000198469


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000904 cell morphogenesis involved in differentiation IGI
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007601 visual perception IGI
 biological_processGO:0014002 astrocyte development IGI
 biological_processGO:0060041 retina development in camera-type eye IGI
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IDA


Pathways (from Reactome)
Pathway description
Laminin interactions
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grem1tm1Ecan/Grem1+,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grem1tm1Ecan/Grem1+,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs,Lamc3tm1.1Wjbr/Lamc3tm1.1Wjbr
Genetic Background: B6.129-Lamc3tm1.1Wjbr Lamb2tm1Jrs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019846 Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*  / complex
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / complex
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / complex
 ENSMUSG00000019899 Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*  / complex






 

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