ENSMUSG00000026479


Mus musculus

Features
Gene ID: ENSMUSG00000026479
  
Biological name :Lamc2
  
Synonyms : Lamc2 / laminin subunit gamma 2
  
Possible biological names infered from orthology : Q13753
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 153122756
Gene end: 153186447
  
Corresponding Affymetrix probe sets: 10358787 (MoGene1.0st)   1421279_at (Mouse Genome 430 2.0 Array)   1452505_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027753
Ensembl peptide - ENSMUSP00000139416
Ensembl peptide - ENSMUSP00000140514
NCBI entrez gene - 16782     See in Manteia.
MGI - MGI:99913
RefSeq - NM_008485
RefSeq - XM_011247926
RefSeq - XM_011247927
RefSeq Peptide - NP_032511
swissprot - G5E874
swissprot - Q9R086
Ensembl - ENSMUSG00000026479
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamc2ENSDARG00000068288Danio rerio
 LAMC2ENSG00000058085Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG0000002647842
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG0000002684030
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564724
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442121
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989921
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279621
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290017
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291117
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG0000001984612
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG0000002663910
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG000000200196


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR013032  EGF-like, conserved site
 IPR031082  Laminin subunit gamma-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0048731 system development IEA
 biological_processGO:0070831 basement membrane assembly IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005607 laminin-2 complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Assembly of collagen fibrils and other multimeric structures
Anchoring fibril formation
Laminin interactions
Type I hemidesmosome assembly
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0000578 ulcerated paws "inflammatory, often suppurating lesions on the paws; often become necrotic" [J:17194]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

Allelic Composition: Lamc2jeb/Lamc2tm1Uit
Genetic Background: (129X1/SvJ-Lamc2jeb x B6.Cg-Lamc2tm1Uit)F1

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0001849 ear inflammation "local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0004273 abnormal basal lamina morphology "anomaly in the structure of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0009827 skin detachment "loss of sections of skin either spontaneously or after gentle handling" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0010936 decreased airway resistance "reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0011045 decreased lung elastance "reduced ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0011159 abnormal epidermal-dermal junction morphology "any structural anomaly of the multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction" [PMID:1097542]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0011160 dermal-epidermal separation "the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis" [MGI:csmith]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

Allelic Composition: Lamc2jeb/Lamc2tm1Uit
Genetic Background: (129X1/SvJ-Lamc2jeb x B6.Cg-Lamc2tm1Uit)F1

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0030423 abnormal pinna cartilage morphology "any structural anomaly of the elastic cartilage component of the auricles" [MGI:anna]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

 MP:0030460 enamel pits "presence of small depressions in the dental enamel" [HP:0009722]
Show

Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: 129X1/SvJ-Lamc2jeb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015647 Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*  / complex
 ENSMUSG00000016942 Q9DBI0 / Tmprss6 / Mus musculus transmembrane serine protease 6 (Tmprss6), transcript variant 2, mRNA. / Q8IU80* / transmembrane serine protease 6*  / reaction
 ENSMUSG00000025064 Q07563 / Col17a1 / Collagen alpha-1(XVII) chain 120 kDa linear IgA disease antigen homolog / Q9UMD9* / collagen type XVII alpha 1 chain*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / reaction / complex
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / complex
 ENSMUSG00000015533 Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*  / reaction / complex
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / reaction / complex
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / complex / reaction
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / complex
 ENSMUSG00000020758 Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*  / reaction / complex
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / complex
 ENSMUSG00000022565 Plec / Q9QXS1 / plectin / Q15149*  / reaction / complex
 ENSMUSG00000025510 Cd151 / O35566 / CD151 antigen / P48509* / CD151 molecule (Raph blood group)*  / reaction / complex
 ENSMUSG00000026131 Dst / Q91ZU6 / Dystonin / Q03001*  / complex / reaction
 ENSMUSG00000000957 Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*  / reaction






 

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