ENSMUSG00000026478


Mus musculus

Features
Gene ID: ENSMUSG00000026478
  
Biological name :Lamc1
  
Synonyms : Lamc1 / laminin subunit gamma 1
  
Possible biological names infered from orthology : P11047
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 153218922
Gene end: 153332786
  
Corresponding Affymetrix probe sets: 10358816 (MoGene1.0st)   1423885_at (Mouse Genome 430 2.0 Array)   1423886_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027752
Ensembl peptide - ENSMUSP00000124216
Ensembl peptide - ENSMUSP00000124662
NCBI entrez gene - 226519     See in Manteia.
MGI - MGI:99914
RefSeq - NM_010683
RefSeq Peptide - NP_034813
swissprot - F8VQJ3
swissprot - F6TLW1
swissprot - F6SFQ3
Ensembl - ENSMUSG00000026478
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamc1ENSDARG00000036279Danio rerio
 LAMC1ENSGALG00000004620Gallus gallus
 LAMC1ENSG00000135862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG0000002684042
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG0000002647931
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564728
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989923
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279623
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442123
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290019
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291119
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG0000002663913
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG0000001984611
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG0000002001910


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0022617 extracellular matrix disassembly IEA
 biological_processGO:0031581 hemidesmosome assembly IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005606 laminin-1 complex IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA


Pathways (from Reactome)
Pathway description
Laminin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Lamc1tm1Strl/Lamc1tm1Strl,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0000756 forelimb paralysis "loss of power of voluntary movement in muscles of the forlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Lamc1tm1Strl/Lamc1tm1Strl,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Lamc1tm1Strl/Lamc1tm1Strl,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Lamc1tm1Strl/Lamc1tm1Strl,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003557 absent vas deferens "absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003558 absent uterus "absence of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003604 single kidney 
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003642 absent seminal gland "absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0003994 abnormal dorsal spinal root morphology "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lamc1tm1Umr/Lamc1tm1Umr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005623 abnormal meninges "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008030 abnormal Cajal-Retzius cell morphology "any abnormality of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Umr/Lamc1tm1Umr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Lamc1tm1Umr/Lamc1tm1Umr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Umr/Lamc1tm1Umr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010225 abnormal quadriceps morphology "any structural anomaly of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0010451 kidney microaneurysm "focal dilation of arteriocapillary junctions in the kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010742 increased Schwann cell number "greater than normal number of cells that sheath the axons of the peripheral nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc1tm1Strl/Lamc1tm1.2Strl
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010978 absent ureteric bud "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lamc1Gt(Ex183)Byg/Lamc1Gt(Ex183)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011183 abnormal primitive endoderm morphology "any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011206 absent visceral yolk sac "absence of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [ISBN10:9780123364258, PMID:21123814]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011366 absent metanephros "absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
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Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020452 abnormal axon radial sorting "any anomaly in the process by which immature Schwann cells surround axons of mixed caliber and send cytoplasmic processes that resemble lamellipodia between axons, to progressively choose and segregate the larger axons at the periphery of the bundle" [MGI:smb, PMID:25686621]
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Lamc1tm1Strl/Lamc1tm1Strl,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / reaction / complex
 ENSMUSG00000032796 Lama1 / laminin subunit alpha 1 / P25391*  / complex
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / complex
 ENSMUSG00000019899 Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*  / complex
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / complex
 ENSMUSG00000020758 Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / reaction / complex
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / complex / reaction
 ENSMUSG00000019846 Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*  / complex
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / complex
 ENSMUSG00000015647 Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*  / complex
 ENSMUSG00000001435 P39061 / Col18a1 / Collagen alpha-1(XVIII) chain Endostatin Non-collagenous domain 1 / P39060* / collagen type XVIII alpha 1 chain*  / reaction / complex






 

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